Toxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
TitleToxicity of tetrabromobisphenol A (TBBPA) in zebrafish (Danio rerio) in a partial life-cycle test.
PubliekssamenvattingToxicological effects of the widely used flame retardant, tetrabromobisphenol A (TBBPA) were assessed in a partial life-cycle test with zebrafish (Danio rerio). Exposure of adult fish during 30 days to water-borne TBBPA in nominal concentrations ranging from 0 (control) to 1.5 muM was followed by exposure of the offspring in early life stages up to 47 days posthatching (dph) to the same concentrations. Adults exposed to 3 and 6 muM showed severe disorientation and lethargy shortly after beginning of exposure and were euthanized. Because semistatic exposure resulted in fluctuating water concentrations, pooled fish samples were chemically analyzed for internal dose assessment. Egg production was decreased in fish exposed to TBBPA concentrations of 0.047 muM and higher, and a critical effect level of 7.2 mug/g lipid with a lower 5% confidence limit of 3.9 mug/g lipid for 50% decreased egg production was calculated. Histology of adult ovaries indicated a relative increase of premature oocytes in two surviving females exposed to 1.5 muM. Hatching of TBBPA-exposed larvae was decreased except in animals exposed to 0.375 muM. In the highest exposure concentration, early posthatching mortality was high (81%) in larvae and the surviving juveniles showed a significant predominance of the female phenotype. Exposure of eggs from control parents up to 6 muM TBBPA resulted in increasing malformation and pericardial fluid accumulation from 1.5 muM; at higher concentrations, all embryos failed to hatch. The presented results indicate decreased reproductive success in zebrafish at environmentally relevant TBBPA concentrations.
- Impacts of 17beta-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio).
- Authors: Brion F, Tyler CR, Palazzi X, Laillet B, Porcher JM, Garric J, Flammarion P
- Issue date: 2004 Jun 24
- Disruption of the hypothalamic-pituitary-thyroid axis in zebrafish embryo-larvae following waterborne exposure to BDE-47, TBBPA and BPA.
- Authors: Chan WK, Chan KM
- Issue date: 2012 Feb
- Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches.
- Authors: De Wit M, Keil D, Remmerie N, van der Ven K, van den Brandhof EJ, Knapen D, Witters E, De Coen W
- Issue date: 2008 Dec
- Effects of prolonged exposure to perchlorate on thyroid and reproductive function in zebrafish.
- Authors: Mukhi S, Patiño R
- Issue date: 2007 Apr
- Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio).
- Authors: Parsons A, Lange A, Hutchinson TH, Miyagawa S, Iguchi T, Kudoh T, Tyler CR
- Issue date: 2019 Apr