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    Multi-center study on the simultaneous administration of DPT-IPV and Hib PRP-T vaccines. Part 1. Immunogenicity

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    Authors
    Labadie J
    Sundermann LC
    Rumke HC
    the DPT-IPV Hib vaccine study group
    Series/Report no.
    RIVM Rapport 124001003
    Language
    en
    
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    Title
    Multi-center study on the simultaneous administration of DPT-IPV and Hib PRP-T vaccines. Part 1. Immunogenicity
    Translated Title
    Multi-center studie naar simultane toediening van DKTP en Hib PRP-T vaccins. Deel 1. Immunogeniteit
    Publiekssamenvatting
    Results are presented of a multi-center clinical study into the antibody formation following two vaccination regimens with simultaneous and combined administration of DPT-IPV and Hib PRP-T vaccines. 543 infants were recruited from 42 baby clinics in Apeldoorn, Capelle and Rotterdam. The antibody responses to all vaccine antigens were considered to be sufficient for protection on both study groups. A moderate but statistically significant interference was found with regard to tetanus antibodies, being lower in children who received combined injections than in children who received the separate injections. This negative interference should be interpreted in the light of the advantages of the combined administration of these important vaccines and thus of reducing the number of injections.
    Resultaten worden beschreven van een multi-center klinische studie naar antistofvorming na twee vaccinatieschemas met simultane en gecombineerde toediening van DKTP en Hib PRP-T vaccins. 543 zuigelingen werden gerecruteerd uit 42 consultatiebureaus voor zuigelingen in Apeldoorn, Capelle en Rotterdam. De antistofrespons tegen alle vaccin-antigenen was in beide studiegroepen voldoende voor bescherming hiertegen. Een matige, maar statistisch significante interferentie werd gevonden bij de tetanus antistoffen. Deze waren lager in de groep kinderen die gecombineerde injecties kreeg dan in de groep die de injecties apart kreeg. Deze negatieve beinvloeding moet worden geinterpreteerd in het licht van de voordelen van gecombineerde toediening van deze belangrijke vaccins, waardoor het aantal injecties kan worden verminderd.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    URI
    http://hdl.handle.net/10029/9890
    Collections
    RIVM official reports

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