• Login
    View Item 
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    RIVM Publications RepositoryCommunitiesTitleAuthorsIssue DateSubmit Date

    My Account

    LoginRegister

    Statistics

    Display statistics

    Infectious gastroenteritis - opportunities for dose response modeling

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    284550003.pdf
    Size:
    2.213Mb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Teunis PFM
    Series/Report no.
    RIVM rapport 284550003
    Type
    Report
    Language
    en
    
    Metadata
    Show full item record
    Title
    Infectious gastroenteritis - opportunities for dose response modeling
    Translated Title
    Infectieuze gastro-enteritis - mogelijkheden voor dosis-responsmodellering
    Publiekssamenvatting
    When pathogenic microorganisms enter the human body via ingestion of food or drinking water, they encounter a system of barriers mounted by the host. Defense mechanisms against microbial infection and invasion may be immunological or non-immunological. To reach parts of the intestinal tract that are suitable for growth and attachment, they must overcome each of the barriers successfully. According to the present view on infection, at least one of the ingested pathogens must survive if colonization is to start. This is the basis for dose response models used for quantitative risk assessment. The validity of such a model, the Beta Poisson model, was demonstrated for multiple barriers, with some attention being given to the single-hit principle. Also discussed was an approach to the derivation of the Beta Poisson model, an aspect which is usually neglected. This approach was shown here to produce results for certain parameter values that were different from the exact formula. Finally, several initiatives for new models are presented in which extra information on infection and illness is incorporated.
    Pathogene micro-organismen die het menselijk lichaam binnendringen via voeding of door het drinken van besmet water, krijgen te maken met een door de gastheer opgeworpen systeem van barrieres. Teneinde delen van het spijsverteringskanaal te bereiken die geschikt zijn voor groei en hechting, moet elk van de tussenliggende barrieres overwonnen worden. De gangbare visie op infectie gaat ervan uit dat minstens een van de ingeslikte pathogenen moet overleven om te kunnen koloniseren. Dit is de basis voor dosis-responsmodellen zoals toegepast bij de microbiologische risico-analyse. Afweermechanismen tegen infectie en invasie door micro-organismen kunnen immunologisch zijn of non-immunologisch. In dit rapport wordt de geldigheid van het Beta-Poissonmodel voor meer dan een barriere gedemonstreerd en wordt enige aandacht besteed aan het 'single-hit' principe. Ook besproken wordt een benadering in de afleiding van het Beta-Poissonmodel, en aangetoond wordt dat deze benadering voor bepaalde parameterwaarden resultaten oplevert die verschillen van de exacte formule. Tenslotte worden enkele aanzetten gedaan tot modellen, waarbij extra informatie over infectie en ziekte kan worden gebruikt.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    URI
    http://hdl.handle.net/10029/9967
    Collections
    RIVM official reports

    entitlement

     

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.