Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621334
Title:
Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus.
Authors:
Campagnolo, Luisa; Massimiani, Micol; Vecchione, Lucia; Piccirilli, Diletta; Toschi, Nicola; Magrini, Andrea; Bonanno, Elena; Scimeca, Manuel; Castagnozzi, Luca; Buonanno, Giorgio; Stabile, Luca; Cubadda, Francesco; Aureli, Federica; Fokkens, Paul Hb; Kreyling, Wolfgang G; Cassee, Flemming R; Pietroiusti, Antonio
Abstract:
Recently, interest for the potential impact of consumer-relevant engineered nanoparticles on pregnancy has dramatically increased. This study investigates whether inhaled silver nanoparticles (AgNPs) reach and cross mouse placental barrier and induce adverse effects. Apart from their relevance for the growing use in consumer products and biomedical applications, AgNPs are selected since they can be unequivocally identified in tissues. Pregnant mouse females are exposed during the first 15 days of gestation by nose-only inhalation to a freshly produced aerosol of 18-20 nm AgNPs for either 1 or 4 h, at a particle number concentration of 3.80 × 107 part./cm-3 and at a mass concentration of 640 μg/m³. AgNPs are identified and quantitated in maternal tissues, placentas and foetuses by transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy and single-particle inductively coupled plasma mass spectrometry. Inhalation of AgNPs results in increased number of resorbed foetuses associated with reduced oestrogen plasma levels, in the 4 h/day exposed mothers. Increased expression of pregnancy-relevant inflammatory cytokines is also detected in the placentas of both groups. These results prove that NPs are able to reach and cross the mouse placenta and suggest that precaution should be taken with respect to acute exposure to nanoparticles during pregnancy.
Citation:
Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus. 2017, 11 (5):687-698 Nanotoxicology
Journal:
Nanotoxicology 2017; 11(5):687-98
Issue Date:
Jun-2017
URI:
http://hdl.handle.net/10029/621334
DOI:
10.1080/17435390.2017.1343875
PubMed ID:
28618895
Type:
Article
Language:
en
ISSN:
1743-5404
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorCampagnolo, Luisaen
dc.contributor.authorMassimiani, Micolen
dc.contributor.authorVecchione, Luciaen
dc.contributor.authorPiccirilli, Dilettaen
dc.contributor.authorToschi, Nicolaen
dc.contributor.authorMagrini, Andreaen
dc.contributor.authorBonanno, Elenaen
dc.contributor.authorScimeca, Manuelen
dc.contributor.authorCastagnozzi, Lucaen
dc.contributor.authorBuonanno, Giorgioen
dc.contributor.authorStabile, Lucaen
dc.contributor.authorCubadda, Francescoen
dc.contributor.authorAureli, Federicaen
dc.contributor.authorFokkens, Paul Hben
dc.contributor.authorKreyling, Wolfgang Gen
dc.contributor.authorCassee, Flemming Ren
dc.contributor.authorPietroiusti, Antonioen
dc.date.accessioned2018-02-07T07:45:40Z-
dc.date.available2018-02-07T07:45:40Z-
dc.date.issued2017-06-
dc.identifier.citationSilver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus. 2017, 11 (5):687-698 Nanotoxicologyen
dc.identifier.issn1743-5404-
dc.identifier.pmid28618895-
dc.identifier.doi10.1080/17435390.2017.1343875-
dc.identifier.urihttp://hdl.handle.net/10029/621334-
dc.description.abstractRecently, interest for the potential impact of consumer-relevant engineered nanoparticles on pregnancy has dramatically increased. This study investigates whether inhaled silver nanoparticles (AgNPs) reach and cross mouse placental barrier and induce adverse effects. Apart from their relevance for the growing use in consumer products and biomedical applications, AgNPs are selected since they can be unequivocally identified in tissues. Pregnant mouse females are exposed during the first 15 days of gestation by nose-only inhalation to a freshly produced aerosol of 18-20 nm AgNPs for either 1 or 4 h, at a particle number concentration of 3.80 × 107 part./cm-3 and at a mass concentration of 640 μg/m³. AgNPs are identified and quantitated in maternal tissues, placentas and foetuses by transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy and single-particle inductively coupled plasma mass spectrometry. Inhalation of AgNPs results in increased number of resorbed foetuses associated with reduced oestrogen plasma levels, in the 4 h/day exposed mothers. Increased expression of pregnancy-relevant inflammatory cytokines is also detected in the placentas of both groups. These results prove that NPs are able to reach and cross the mouse placenta and suggest that precaution should be taken with respect to acute exposure to nanoparticles during pregnancy.en
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.subject.meshAnimals-
dc.subject.meshCytokines-
dc.subject.meshFemale-
dc.subject.meshInhalation Exposure-
dc.subject.meshMaternal Exposure-
dc.subject.meshMetal Nanoparticles-
dc.subject.meshMice-
dc.subject.meshPlacenta-
dc.subject.meshPregnancy-
dc.subject.meshSilver-
dc.titleSilver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus.en
dc.typeArticleen
dc.identifier.journalNanotoxicology 2017; 11(5):687-98en

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