A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621806
Title:
A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.
Authors:
van den Berg, Rosa; Kooijman, Sander; Noordam, Raymond; Ramkisoensing, Ashna; Abreu-Vieira, Gustavo; Tambyrajah, Lauren L; Dijk, Wieneke; Ruppert, Philip; Mol, Isabel M; Kramar, Barbara; Caputo, Rosanna; Puig, Laura Sardón; de Ruiter, Evelien M; Kroon, Jan; Hoekstra, Menno; van der Sluis, Ronald J; Meijer, Onno C; Willems van Dijk, Ko; van Kerkhof, Linda W M; Christodoulides, Constantinos; Karpe, Fredrik; Gerhart-Hines, Zachary; Kersten, Sander; Meijer, Johanna H; Coomans, Claudia P; van Heemst, Diana; Biermasz, Nienke R; Rensen, Patrick C N
Abstract:
Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.
Citation:
A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. 2018, 22 (13):3521-3533 Cell Rep
Journal:
Cell Rep 2018; 22(13):3521-33
Issue Date:
27-Mar-2018
URI:
http://hdl.handle.net/10029/621806
DOI:
10.1016/j.celrep.2018.03.004
PubMed ID:
29590620
Type:
Article
Language:
en
ISSN:
2211-1247
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorvan den Berg, Rosaen
dc.contributor.authorKooijman, Sanderen
dc.contributor.authorNoordam, Raymonden
dc.contributor.authorRamkisoensing, Ashnaen
dc.contributor.authorAbreu-Vieira, Gustavoen
dc.contributor.authorTambyrajah, Lauren Len
dc.contributor.authorDijk, Wienekeen
dc.contributor.authorRuppert, Philipen
dc.contributor.authorMol, Isabel Men
dc.contributor.authorKramar, Barbaraen
dc.contributor.authorCaputo, Rosannaen
dc.contributor.authorPuig, Laura Sardónen
dc.contributor.authorde Ruiter, Evelien Men
dc.contributor.authorKroon, Janen
dc.contributor.authorHoekstra, Mennoen
dc.contributor.authorvan der Sluis, Ronald Jen
dc.contributor.authorMeijer, Onno Cen
dc.contributor.authorWillems van Dijk, Koen
dc.contributor.authorvan Kerkhof, Linda W Men
dc.contributor.authorChristodoulides, Constantinosen
dc.contributor.authorKarpe, Fredriken
dc.contributor.authorGerhart-Hines, Zacharyen
dc.contributor.authorKersten, Sanderen
dc.contributor.authorMeijer, Johanna Hen
dc.contributor.authorCoomans, Claudia Pen
dc.contributor.authorvan Heemst, Dianaen
dc.contributor.authorBiermasz, Nienke Ren
dc.contributor.authorRensen, Patrick C Nen
dc.date.accessioned2018-04-19T09:50:48Z-
dc.date.available2018-04-19T09:50:48Z-
dc.date.issued2018-03-27-
dc.identifier.citationA Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. 2018, 22 (13):3521-3533 Cell Repen
dc.identifier.issn2211-1247-
dc.identifier.pmid29590620-
dc.identifier.doi10.1016/j.celrep.2018.03.004-
dc.identifier.urihttp://hdl.handle.net/10029/621806-
dc.description.abstractMany favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.en
dc.language.isoenen
dc.rightsArchived with thanks to Cell reportsen
dc.titleA Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.en
dc.typeArticleen
dc.identifier.journalCell Rep 2018; 22(13):3521-33en

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