Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621808
Title:
Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.
Authors:
Vidal, Arnau; Claeys, Liesel; Mengelers, Marcel; Vanhoorne, Valérie; Vervaet, Chris; Huybrechts, Bart; De Saeger, Sarah; De Boevre, Marthe
Abstract:
For the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a single bolus of 1 µg/kg body weight of DON and a single bolus of 1 µg/kg body weight of DON-3-glucoside after a washing-out period of two months was administered, and a 24-h urine collection was performed. The urine was analysed for DON, DON-3-glucoside, 3-ADON, 15-ADON, deepoxy-deoxynivalenol (DOM-1), deoxynivalenol-3-glucuronide (DON-3-glucuronide) and deoxynivalenol-15-glucuronide (DON-15-glucuronide). The urinary biomarker-analysis revealed that DON and DON-3-glucoside were rapidly absorbed, distributed, metabolized and excreted. Sixty-four % of the administered DON and 58% of DON-3-glucoside was recovered in the urine collected within 24 h. DON-15-glucuronide was the most prominent urinary biomarker followed by free DON and DON-3-glucuronide. Moreover, correlations among the presence of DON-15-glucuronide and DON-3-glucuronide were observed (within 24 hours (r = 0.61)). The DOM-1 detected in the urine was higher after the DON-3-glucoside administration. The obtained results are imperative to construct a standardized method to estimate DON-intake by means of urinary biomarkers.
Citation:
Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. 2018, 8 (1):5255 Sci Rep
Journal:
Sci Rep 2018; 8(1):5255
Issue Date:
27-Mar-2018
URI:
http://hdl.handle.net/10029/621808
DOI:
10.1038/s41598-018-23526-9
PubMed ID:
29588479
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorVidal, Arnauen
dc.contributor.authorClaeys, Lieselen
dc.contributor.authorMengelers, Marcelen
dc.contributor.authorVanhoorne, Valérieen
dc.contributor.authorVervaet, Chrisen
dc.contributor.authorHuybrechts, Barten
dc.contributor.authorDe Saeger, Sarahen
dc.contributor.authorDe Boevre, Martheen
dc.date.accessioned2018-04-19T09:53:21Z-
dc.date.available2018-04-19T09:53:21Z-
dc.date.issued2018-03-27-
dc.identifier.citationHumans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. 2018, 8 (1):5255 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid29588479-
dc.identifier.doi10.1038/s41598-018-23526-9-
dc.identifier.urihttp://hdl.handle.net/10029/621808-
dc.description.abstractFor the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a single bolus of 1 µg/kg body weight of DON and a single bolus of 1 µg/kg body weight of DON-3-glucoside after a washing-out period of two months was administered, and a 24-h urine collection was performed. The urine was analysed for DON, DON-3-glucoside, 3-ADON, 15-ADON, deepoxy-deoxynivalenol (DOM-1), deoxynivalenol-3-glucuronide (DON-3-glucuronide) and deoxynivalenol-15-glucuronide (DON-15-glucuronide). The urinary biomarker-analysis revealed that DON and DON-3-glucoside were rapidly absorbed, distributed, metabolized and excreted. Sixty-four % of the administered DON and 58% of DON-3-glucoside was recovered in the urine collected within 24 h. DON-15-glucuronide was the most prominent urinary biomarker followed by free DON and DON-3-glucuronide. Moreover, correlations among the presence of DON-15-glucuronide and DON-3-glucuronide were observed (within 24 hours (r = 0.61)). The DOM-1 detected in the urine was higher after the DON-3-glucoside administration. The obtained results are imperative to construct a standardized method to estimate DON-intake by means of urinary biomarkers.en
dc.language.isoenen
dc.rightsArchived with thanks to Scientific reportsen
dc.titleHumans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.en
dc.typeArticleen
dc.identifier.journalSci Rep 2018; 8(1):5255en

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