Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621952
Title:
Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.
Authors:
van Oostrom, Sandra H; Engelfriet, Peter M; Verschuren, W M Monique; Schipper, Maarten; Wouters, Inge M; Boezen, Marike; Smit, Henriëtte A; Kerstjens, Huib A M; Picavet, H Susan J
Abstract:
The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards. Participants were included in this study if spirometric measurement of FEV1, which in this study was the main parameter of interest, was acceptable and reproducible on at least one measurement round, leading to the inclusion of 5727 individuals (3008 females). Statistical analysis revealed three typical trajectories. The majority of participants followed a trajectory that closely adhered to the Global Lung Initiative Reference values (94.9% of men and 96.4% of women). Two other trajectories showed a more pronounced decline. Smoking and the presence of respiratory complaints were the best predictors of a trajectory with stronger decline. A greater BMI over the follow-up period was associated with a more unfavorable FEV1 course both in men (β = -0.027 (SD = 0.002); P < 0.001) and in women (β = -0.008 (SD = 0.001); P < 0.001). Smokers at baseline who quit the habit during follow-up, showed smaller decline in FEV1 in comparison to persistent smokers, independent of BMI change (In men β = -0.074 (SD = 0.020); P < 0.001. In women β = -0.277 (SD = 0.068); P < 0.001). In conclusion, three typical trajectories of age-related FEV1 decline could be distinguished. Change in the lifestyle related risk factors, BMI and smoking, significantly impact aging-related decline of lung function. Identifying deviant trajectories may help in early recognition of those at risk of a diagnosis of lung disease later in life.
Citation:
Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study. 2018, 13 (5):e0197250 PLoS ONE
Journal:
Plos One 2018; 13(5):e0197250
Issue Date:
2018
URI:
http://hdl.handle.net/10029/621952
DOI:
10.1371/journal.pone.0197250
PubMed ID:
29768509
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorvan Oostrom, Sandra Hen
dc.contributor.authorEngelfriet, Peter Men
dc.contributor.authorVerschuren, W M Moniqueen
dc.contributor.authorSchipper, Maartenen
dc.contributor.authorWouters, Inge Men
dc.contributor.authorBoezen, Marikeen
dc.contributor.authorSmit, Henriëtte Aen
dc.contributor.authorKerstjens, Huib A Men
dc.contributor.authorPicavet, H Susan Jen
dc.date.accessioned2018-05-27T13:07:21Z-
dc.date.available2018-05-27T13:07:21Z-
dc.date.issued2018-
dc.identifier.citationAging-related trajectories of lung function in the general population-The Doetinchem Cohort Study. 2018, 13 (5):e0197250 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid29768509-
dc.identifier.doi10.1371/journal.pone.0197250-
dc.identifier.urihttp://hdl.handle.net/10029/621952-
dc.description.abstractThe objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards. Participants were included in this study if spirometric measurement of FEV1, which in this study was the main parameter of interest, was acceptable and reproducible on at least one measurement round, leading to the inclusion of 5727 individuals (3008 females). Statistical analysis revealed three typical trajectories. The majority of participants followed a trajectory that closely adhered to the Global Lung Initiative Reference values (94.9% of men and 96.4% of women). Two other trajectories showed a more pronounced decline. Smoking and the presence of respiratory complaints were the best predictors of a trajectory with stronger decline. A greater BMI over the follow-up period was associated with a more unfavorable FEV1 course both in men (β = -0.027 (SD = 0.002); P < 0.001) and in women (β = -0.008 (SD = 0.001); P < 0.001). Smokers at baseline who quit the habit during follow-up, showed smaller decline in FEV1 in comparison to persistent smokers, independent of BMI change (In men β = -0.074 (SD = 0.020); P < 0.001. In women β = -0.277 (SD = 0.068); P < 0.001). In conclusion, three typical trajectories of age-related FEV1 decline could be distinguished. Change in the lifestyle related risk factors, BMI and smoking, significantly impact aging-related decline of lung function. Identifying deviant trajectories may help in early recognition of those at risk of a diagnosis of lung disease later in life.en
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.en
dc.typeArticleen
dc.identifier.journalPlos One 2018; 13(5):e0197250en

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