Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621956
Title:
Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Authors:
Zamora-Ros, Raul; Cayssials, Valerie; Jenab, Mazda; Rothwell, Joseph A; Fedirko, Veronika; Aleksandrova, Krasimira; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Mahamat-Saleh, Yahya; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Valanou, Elissavet; Vasilopoulou, Effie; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Weiderpass, Elisabete; Lukic, Marko; Sandanger, Torkjel M; Lasheras, Cristina; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Navarro, Carmen; Ardanaz, Eva; Sonestedt, Emily; Ohlsson, Bodil; Nilsson, Lena Maria; Rutegård, Martin; Bueno-de-Mesquita, Bas; Peeters, Petra H; Khaw, Kay-Thee; Wareham, Nicholas J; Bradbury, Kathryn; Freisling, Heinz; Romieu, Isabelle; Cross, Amanda J; Vineis, Paolo; Scalbert, Augustin
Abstract:
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
Citation:
Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. 2018 Eur. J. Epidemiol.
Journal:
Eur J Epidemiol 2018; advance online publication (ahead of print)
Issue Date:
15-May-2018
URI:
http://hdl.handle.net/10029/621956
DOI:
10.1007/s10654-018-0408-6
PubMed ID:
29761424
Type:
Article
Language:
en
ISSN:
1573-7284
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorZamora-Ros, Raulen
dc.contributor.authorCayssials, Valerieen
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorRothwell, Joseph Aen
dc.contributor.authorFedirko, Veronikaen
dc.contributor.authorAleksandrova, Krasimiraen
dc.contributor.authorTjønneland, Anneen
dc.contributor.authorKyrø, Cecilieen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorBoutron-Ruault, Marie-Christineen
dc.contributor.authorCarbonnel, Francken
dc.contributor.authorMahamat-Saleh, Yahyaen
dc.contributor.authorKaaks, Rudolfen
dc.contributor.authorKühn, Tilmanen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorValanou, Elissaveten
dc.contributor.authorVasilopoulou, Effieen
dc.contributor.authorMasala, Giovannaen
dc.contributor.authorPala, Valeriaen
dc.contributor.authorPanico, Salvatoreen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorRicceri, Fulvioen
dc.contributor.authorWeiderpass, Elisabeteen
dc.contributor.authorLukic, Markoen
dc.contributor.authorSandanger, Torkjel Men
dc.contributor.authorLasheras, Cristinaen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorSánchez, Maria-Joseen
dc.contributor.authorAmiano, Pilaren
dc.contributor.authorNavarro, Carmenen
dc.contributor.authorArdanaz, Evaen
dc.contributor.authorSonestedt, Emilyen
dc.contributor.authorOhlsson, Bodilen
dc.contributor.authorNilsson, Lena Mariaen
dc.contributor.authorRutegård, Martinen
dc.contributor.authorBueno-de-Mesquita, Basen
dc.contributor.authorPeeters, Petra Hen
dc.contributor.authorKhaw, Kay-Theeen
dc.contributor.authorWareham, Nicholas Jen
dc.contributor.authorBradbury, Kathrynen
dc.contributor.authorFreisling, Heinzen
dc.contributor.authorRomieu, Isabelleen
dc.contributor.authorCross, Amanda Jen
dc.contributor.authorVineis, Paoloen
dc.contributor.authorScalbert, Augustinen
dc.date.accessioned2018-05-27T13:13:34Z-
dc.date.available2018-05-27T13:13:34Z-
dc.date.issued2018-05-15-
dc.identifier.citationDietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. 2018 Eur. J. Epidemiol.en
dc.identifier.issn1573-7284-
dc.identifier.pmid29761424-
dc.identifier.doi10.1007/s10654-018-0408-6-
dc.identifier.urihttp://hdl.handle.net/10029/621956-
dc.description.abstractPolyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.en
dc.language.isoenen
dc.rightsArchived with thanks to European journal of epidemiologyen
dc.titleDietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.en
dc.typeArticleen
dc.identifier.journalEur J Epidemiol 2018; advance online publication (ahead of print)en

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