Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives.

2.50
Hdl Handle:
http://hdl.handle.net/10029/622071
Title:
Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives.
Authors:
Hristozov, Danail; Pizzol, Lisa; Basei, Gianpietro; Zabeo, Alex; Mackevica, Aiga; Hansen, Steffen Foss; Gosens, Ilse; Cassee, Flemming R; de Jong, Wim; Koivisto, Antti Joonas; Neubauer, Nicole; Sanchez Jimenez, Araceli; Semenzin, Elena; Subramanian, Vrishali; Fransman, Wouter; Jensen, Keld Alstrup; Wohlleben, Wendel; Stone, Vicki; Marcomini, Antonio
Abstract:
The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the lifecycles of these formulations used in antibacterial and antifungal wood coatings and impregnations by means of the EU FP7 SUN project's Decision Support System (SUNDS, www.sunds.gd). The results from the risk analysis revealed inhalation risks from CuO in exposure scenarios involving workers handling dry powders and performing sanding operations as well as potential ingestion risks for children exposed to nano Cu2(OH)2CO3 in a scenario involving hand-to-mouth transfer of the substance released from impregnated wood. There are, however, substantial uncertainties in these results, so some of the identified risks may stem from the safety margin of extrapolation to fill data gaps and might be resolved by additional testing. Our stochastic approach successfully communicated the contribution of different sources of uncertainty in the risk assessment. The main source of uncertainty was the extrapolation from short to long-term exposure, which was necessary due to the lack of (sub)chronic in vivo studies with CuO and Cu2(OH)2CO3. Considerable uncertainties also stemmed from the use of default inter- and intra-species extrapolation factors.
Citation:
Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives. 2018:1-19 Nanotoxicology
Journal:
Nanotoxicology 2018; 12:1-19
Issue Date:
12-Jun-2018
URI:
http://hdl.handle.net/10029/622071
DOI:
10.1080/17435390.2018.1472314
PubMed ID:
29893192
Type:
Article
Language:
en
ISSN:
1743-5404
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorHristozov, Danailen
dc.contributor.authorPizzol, Lisaen
dc.contributor.authorBasei, Gianpietroen
dc.contributor.authorZabeo, Alexen
dc.contributor.authorMackevica, Aigaen
dc.contributor.authorHansen, Steffen Fossen
dc.contributor.authorGosens, Ilseen
dc.contributor.authorCassee, Flemming Ren
dc.contributor.authorde Jong, Wimen
dc.contributor.authorKoivisto, Antti Joonasen
dc.contributor.authorNeubauer, Nicoleen
dc.contributor.authorSanchez Jimenez, Aracelien
dc.contributor.authorSemenzin, Elenaen
dc.contributor.authorSubramanian, Vrishalien
dc.contributor.authorFransman, Wouteren
dc.contributor.authorJensen, Keld Alstrupen
dc.contributor.authorWohlleben, Wendelen
dc.contributor.authorStone, Vickien
dc.contributor.authorMarcomini, Antonioen
dc.date.accessioned2018-07-17T12:58:21Z-
dc.date.available2018-07-17T12:58:21Z-
dc.date.issued2018-06-12-
dc.identifier.citationQuantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives. 2018:1-19 Nanotoxicologyen
dc.identifier.issn1743-5404-
dc.identifier.pmid29893192-
dc.identifier.doi10.1080/17435390.2018.1472314-
dc.identifier.urihttp://hdl.handle.net/10029/622071-
dc.description.abstractThe use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the lifecycles of these formulations used in antibacterial and antifungal wood coatings and impregnations by means of the EU FP7 SUN project's Decision Support System (SUNDS, www.sunds.gd). The results from the risk analysis revealed inhalation risks from CuO in exposure scenarios involving workers handling dry powders and performing sanding operations as well as potential ingestion risks for children exposed to nano Cu2(OH)2CO3 in a scenario involving hand-to-mouth transfer of the substance released from impregnated wood. There are, however, substantial uncertainties in these results, so some of the identified risks may stem from the safety margin of extrapolation to fill data gaps and might be resolved by additional testing. Our stochastic approach successfully communicated the contribution of different sources of uncertainty in the risk assessment. The main source of uncertainty was the extrapolation from short to long-term exposure, which was necessary due to the lack of (sub)chronic in vivo studies with CuO and Cu2(OH)2CO3. Considerable uncertainties also stemmed from the use of default inter- and intra-species extrapolation factors.en
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleQuantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives.en
dc.typeArticleen
dc.identifier.journalNanotoxicology 2018; 12:1-19en

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