Health impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products.

2.50
Hdl Handle:
http://hdl.handle.net/10029/622073
Title:
Health impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products.
Authors:
Jongeneel, W P; Delmaar, J E; Bokkers, B G H
Abstract:
A methodology to assess the health impact of skin sensitizers is introduced, which consists of the comparison of the probabilistic aggregated exposure with a probabilistic (individual) human sensitization or elicitation induction dose. The health impact of potential policy measures aimed at reducing the concentration of a fragrance allergen, geraniol, in consumer products is analysed in a simulated population derived from multiple product use surveys. Our analysis shows that current dermal exposure to geraniol from personal care and household cleaning products lead to new cases of contact allergy and induce clinical symptoms for those already sensitized. We estimate that this exposure results yearly in 34 new cases of geraniol contact allergy per million consumers in Western and Northern Europe, mainly due to exposure to household cleaning products. About twice as many consumers (60 per million) are projected to suffer from clinical symptoms due to re-exposure to geraniol. Policy measures restricting geraniol concentrations to <0.01% will noticeably reduce new cases of sensitization and decrease the number of people with clinical symptoms as well as the frequency of occurrence of these clinical symptoms. The estimated numbers should be interpreted with caution and provide only a rough indication of the health impact.
Citation:
Health impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products. 2018, 118:235-244 Environ Int
Journal:
Environ Int 2018; 118:235-44
Issue Date:
Sep-2018
URI:
http://hdl.handle.net/10029/622073
DOI:
10.1016/j.envint.2018.04.039
PubMed ID:
29890471
Type:
Article
Language:
en
ISSN:
1873-6750
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorJongeneel, W Pen
dc.contributor.authorDelmaar, J Een
dc.contributor.authorBokkers, B G Hen
dc.date.accessioned2018-07-17T13:01:23Z-
dc.date.available2018-07-17T13:01:23Z-
dc.date.issued2018-09-
dc.identifier.citationHealth impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products. 2018, 118:235-244 Environ Inten
dc.identifier.issn1873-6750-
dc.identifier.pmid29890471-
dc.identifier.doi10.1016/j.envint.2018.04.039-
dc.identifier.urihttp://hdl.handle.net/10029/622073-
dc.description.abstractA methodology to assess the health impact of skin sensitizers is introduced, which consists of the comparison of the probabilistic aggregated exposure with a probabilistic (individual) human sensitization or elicitation induction dose. The health impact of potential policy measures aimed at reducing the concentration of a fragrance allergen, geraniol, in consumer products is analysed in a simulated population derived from multiple product use surveys. Our analysis shows that current dermal exposure to geraniol from personal care and household cleaning products lead to new cases of contact allergy and induce clinical symptoms for those already sensitized. We estimate that this exposure results yearly in 34 new cases of geraniol contact allergy per million consumers in Western and Northern Europe, mainly due to exposure to household cleaning products. About twice as many consumers (60 per million) are projected to suffer from clinical symptoms due to re-exposure to geraniol. Policy measures restricting geraniol concentrations to <0.01% will noticeably reduce new cases of sensitization and decrease the number of people with clinical symptoms as well as the frequency of occurrence of these clinical symptoms. The estimated numbers should be interpreted with caution and provide only a rough indication of the health impact.en
dc.language.isoenen
dc.rightsArchived with thanks to Environment internationalen
dc.titleHealth impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products.en
dc.typeArticleen
dc.identifier.journalEnviron Int 2018; 118:235-44en
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