Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Milder, Ivon E JFeskens, Edith J M
Arts, Ilja C W
Bueno-de-Mesquita, H Bas
Hollman, Peter C H
Kromhout, Daan
Type
ArticleLanguage
en
Metadata
Show full item recordTitle
Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study.Publiekssamenvatting
BACKGROUND: Plant lignans are converted to enterolignans that have antioxidant and weak estrogen-like activities, and therefore they may lower cardiovascular disease and cancer risks. OBJECTIVE: We investigated whether the intakes of 4 plant lignans (lariciresinol, pinoresinol, secoisolariciresinol, and matairesinol) were inversely associated with coronary heart disease (CHD), cardiovascular diseases (CVD), cancer, and all-cause mortality. DESIGN: The Zutphen Elderly Study is a prospective cohort study in which 570 men aged 64-84 y were followed for 15 y. We recently developed a database and used it to estimate the dietary intakes of 4 plant lignans. Lignan intake was related to mortality with the use of Cox proportional hazards analysis. RESULTS: The median total lignan intake in 1985 was 977 microg/d. Tea, vegetables, bread, coffee, fruit, and wine were the major sources of lignan. The total lignan intake was not related to mortality. However, the intake of matairesinol was inversely associated with CHD, CVD, and all-cause mortality (P = 0.05 for all) and cancer (P = 0.06). Multivariate-adjusted rate ratios (95% CI) per 1-SD increase in intake were 0.72 (0.53, 0.98) for CHD, 0.83 (0.69, 1.00) for CVD, 0.86 (0.76, 0.97) for all-cause mortality, and 0.81 (0.65, 1.00) for cancer. CONCLUSIONS: Total lignan intake was not associated with mortality. The intake of matairesinol was inversely associated with mortality due to CHD, CVD, cancer, and all causes. We cannot exclude the possibility that the inverse association between matairesinol intake and mortality is due to an associated factor, such as wine consumption.PMID
16895890Collections
Related articles
- Intake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in Dutch men and women.
- Authors: Milder IE, Feskens EJ, Arts IC, Bueno de Mesquita HB, Hollman PC, Kromhout D
- Issue date: 2005 May
- Intake of the plant lignans matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol in relation to vascular inflammation and endothelial dysfunction in middle age-elderly men and post-menopausal women living in Northern Italy.
- Authors: Pellegrini N, Valtueña S, Ardigò D, Brighenti F, Franzini L, Del Rio D, Scazzina F, Piatti PM, Zavaroni I
- Issue date: 2010 Jan
- Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol.
- Authors: Milder IE, Arts IC, van de Putte B, Venema DP, Hollman PC
- Issue date: 2005 Mar
- Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status.
- Authors: Touillaud MS, Thiébaut AC, Fournier A, Niravong M, Boutron-Ruault MC, Clavel-Chapelon F
- Issue date: 2007 Mar 21
- Dietary intake and major sources of plant lignans in Latvian men and women.
- Authors: Meija L, Söderholm P, Samaletdin A, Ignace G, Siksna I, Joffe R, Lejnieks A, Lietuvietis V, Krams I, Adlercreutz H
- Issue date: 2013 Aug