Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort.
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Authors
Rinaldi, SabinaKey, Timothy J
Peeters, Petra H M
Lahmann, Petra H
Lukanova, Annekatrin
Dossus, Laure
Biessy, Carine
Vineis, Paolo
Sacerdote, Carlotta
Berrino, Franco
Panico, Salvatore
Tumino, Rosario
Palli, Domenico
Nagel, Gabriele
Linseisen, Jakob
Boeing, Heiner
Roddam, Andrew
Bingham, Sheila A
Khaw, Kay-Tee
Chloptios, John
Trichopoulou, Antonia
Trichopoulos, Dimitrios
Tehard, Bertrand
Clavel-Chapelon, Françoise
González, Carlos Alberto
Larrañaga, Nerea
Barricarte, Aurelio
Quirós, José Ramón
Chirlaque, María-Dolores
Martinez, Carmen
Monninkhof, Evelyn
Grobbee, Diederick E
Bueno-de-Mesquita, H Bas
Ferrari, Pietro
Slimani, Nadia
Riboli, Elio
Kaaks, Rudolf
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ArticleLanguage
en
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Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort.Publiekssamenvatting
In a large case-control study on breast cancer risk and serum hormone concentrations, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we examined to what extent the relationship of excess body weight with breast cancer risk may be explained by changes in sex steroids. Height, weight, waist and hip circumferences, and serum measurements of testosterone [T], androstenedione [Delta4], dehydroepiandrosterone sulphate [DHEAS], estradiol [E2], estrone [E1] and sex-hormone binding globulin [SHBG] were available for 613 breast cancer cases, and 1,139 matched controls, who were all menopausal at the time of blood donation. Free T [fT] and free E2 [fE2] were calculated using mass action equations. Breast cancer risk was related to body mass index (BMI) (RR = 1.11 [0.99-1.25], per 5 kg/m2 increase in BMI), and waist (RR = 1.12 [1.02-1.24], per 10 cm increase) and hip circumferences (RR = 1.14 [1.02-1.27], per 10 cm increase). The increase in breast cancer risk associated with adiposity was substantially reduced after adjustment for any estrogens, especially for fE2 (from 1.11 [0.99-1.25] to 0.99 [0.87-1.12], from 1.12 [1.02-1.24] to 1.02 [0.92-1.14] and from 1.14 [1.02-1.27] to 1.05 [0.93-1.18] for BMI, waist and hip circumferences, respectively). A modest attenuation in excess risk was observed after adjustment for fT, but the remaining androgens had little effect on the association of body adiposity with breast cancer. Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG.PMID
16385576ae974a485f413a2113503eed53cd6c53
10.1002/ijc.21730
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