A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections.

Koenen, Mischa HBosma, MadeleenRoorda, Udo AWopereis, Fabiënne MyRoos, Anjavan der Vries, ErhardBogaert, DebbySanders, Elisabeth AmBoes, MarianneHeidema, Jojannekevan Montfrans, Joris MBalemans, Walter Afvan Holten, Thijs CVerhagen, Lilly M2021-12-232021-12-232021-10-292050-00683474560910.1002/cti2.1344http://hdl.handle.net/10029/625425We developed reference values for IgA for seven age groups and five different laboratory assays. Using these reference values, IgA measurements from 417 cases and 224 controls were standardised to compare groups. In children aged 2 years and older, IgA deficiency was observed in 2.9% (7/242) of cases and 0% (0/189) of controls (P = 0.02).en© 2021 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.IgA deficiencycase–control studyimmunoglobulin Areference valuesrespiratory tract infectionsA novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections.ArticleClin Transl Immunology 2021;10(11):e1344