Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.

Wei, FeixueGaisa, Michael MD'Souza, GypsyamberXia, NingshaoGiuliano, Anna RHawes, Stephen EGao, LeiCheng, Shu-HsingDonà, Maria GabriellaGoldstone, Stephen ESchim van der Loeff, Maarten FNeukam, KarinMeites, ElissaPoynten, I MaryDai, JianghongCombes, Jean-DamienWieland, UlrikeBurgos, JoaquinWilkin, Timothy JHernandez, Alexandra LIribarren Díaz, MauricioHidalgo-Tenorio, CarmenValencia Arredondo, MarlenyNyitray, Alan GWentzensen, NicolasChow, Eric PfSmelov, VitalyNowak, Rebecca GPhanuphak, NittayaWoo, Yin LingChoi, YoojinHu, YifeiSchofield, Alice MWoestenberg, Petra JChikandiwa, Admire THickey, Andrew Cde Pokomandy, AlexandraMurenzi, GadPéré, HélèneDel Pino, MartaOrtiz, Ana PCharnot-Katsikas, AngellaLiu, XingChariyalertsak, SuwatStrong, CarolOng, Jason JYunihastuti, EvyEtienney, IsabelleFerré, Valentine MZou, HuachunSegondy, MichelChinyowa, SimbarasheAlberts, Catharina JClifford, Gary M2021-09-132021-09-132021-07-303433962810.1016/S2352-3018(21)00108-9http://hdl.handle.net/10029/625240The systematic review identified 93 eligible studies, of which 64 contributed data on 29 900 men to the pooled analysis. Among HIV-negative MSW anal HPV16 prevalence was 1·8% (91 of 5190) and HR-HPV prevalence was 6·9% (345 of 5003); among HIV-positive MSW the prevalences were 8·7% (59 of 682) and 26·9% (179 of 666); among HIV-negative MSM they were 13·7% (1455 of 10 617) and 41·2% (3798 of 9215), and among HIV-positive MSM 28·5% (3819 of 13 411) and 74·3% (8765 of 11 803). In HIV-positive MSM, HPV16 prevalence was 5·6% (two of 36) among those age 15-18 years and 28·8% (141 of 490) among those age 23-24 years (ptrend=0·0091); prevalence was 31·7% (1057 of 3337) among those age 25-34 years and 22·8% (451 of 1979) among those age 55 and older (ptrend<0·0001). HPV16 prevalence in HIV-negative MSM was 6·7% (15 of 223) among those age 15-18 and 13·9% (166 of 1192) among those age 23-24 years (ptrend=0·0076); the prevalence plateaued thereafter (ptrend=0·72). Similar age-specific patterns were observed for HR-HPV. No significant differences for HPV16 or HR-HPV were found by age for either HIV-positive or HIV-negative MSW. HSIL+ detection ranged from 7·5% (12 of 160) to 54·5% (61 of 112) in HIV-positive MSM; after adjustment for heterogeneity, HIV was a significant predictor of HSIL+ (aPR 1·54, 95% CI 1·36-1·73), HPV16-positive HSIL+ (1·66, 1·36-2·03), and HSIL+ in HPV16-positive MSM (1·19, 1·04-1·37). Among HPV16-positive MSM, HSIL+ prevalence increased with age.en© 2021 World Health Organization; licensee Elsevier. This is an Open Access article published under the CC BY-NC-ND 3.0 IGO license.Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.Article2352-3018Lancet HIV 2021; 8(9):e531-43