Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with low extraction efficiency

Haenen, BRompelberg, Crivmvan Twillert, KHamzink, MDormans, Jvan Eijkeren, Jrivm2025-03-182025-03-18200211854150https://rivm.openrepository.com/handle/10029/639678Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with low extraction efficiencyArticleDrug Metab Dispos 2002; 30:307-132025-03-18