Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.

Ibi, DorinaBlauw, Lisanne LNoordam, RaymondDollé, Martijn E TJukema, J WouterRosendaal, Frits RChristodoulides, ConstantinosNeville, Matt JKoivula, RobertRensen, Patrick C NKarpe, Fredrikvan Dijk, Ko Willems2021-07-122021-07-122021-05-093405374510.1016/j.atherosclerosis.2021.04.015http://hdl.handle.net/10029/625050Compared to the individual groups with genetically-influenced lower TG or lower LDL-C only, the group with combined genetically-influenced lower TG and LDL-C showed an overall independent and additive pattern of changes in metabolomic measures. Over 100 measures were different (p < 1.35 × 10-3) compared to the reference, with effect sizes and directionality being similar in NEO and OBB. Most notably, levels of all very-low density lipoprotein (VLDL) and LDL sub-particles were lower.enCopyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.Cardiovascular diseaseLDL-Cholesterol-loweringLipoprotein lipaseMendelian randomizationMetabolomicsTriglyceride-loweringTriglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.Article1879-1484Atherosclerosis 2021; 328:144-52