Scher, Ann ITerwindt, Gisela MVerschuren, W M MoniqueKruit, Mark CBlom, Henk JKowa, HisanoriFrants, Rune RMaagdenberg, Arn M J M van denBuchem, Mark A vanFerrari, Michel DLauner, Lenore J2007-01-092007-01-092006-02-01Ann. Neurol. 2006, 59(2):372-50364-51341636587110.1002/ana.20755http://hdl.handle.net/10029/7088OBJECTIVE: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. METHODS: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. RESULTS: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. INTERPRETATION: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.80893 bytesapplication/pdfenArticleYES