van der Lee, SaskiaKemmeren, Jeanet Mde Rond, Lia G HÖztürk, KemalWesterhof, Annekede Melker, Hester ESanders, Elisabeth A MBerbers, Guy A Mvan der Maas, Nicoline A TRümke, Hans CBuisman, Anne-Marie2018-02-072018-02-072017-09Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination. 2017, 36 (9):e223-e229 Pediatr. Infect. Dis. J.1532-09872843075010.1097/INF.0000000000001620http://hdl.handle.net/10029/621343In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.eninfo:eu-repo/semantics/closedAccessAntibodies, BacterialAntigens, BacterialCase-Control StudiesCells, CulturedChild, PreschoolCytokinesDiphtheria-Tetanus-acellular Pertussis VaccinesFemaleHumansImmunization, SecondaryImmunoglobulin GInflammationLeukocytes, MononuclearMaleNetherlandsArticlePediatr Infect Dis J 2017; 36(9):e223-9