Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion.

Camaioni, AntonellaMassimiani, MicolLacconi, ValentinaMagrini, AndreaSalustri, AntoniettaSotiriou, Georgios ASingh, DilpreetBitounis, DimitriosBocca, BeatricePino, AnnaBarone, FlaviaProta, ValentinaIavicoli, IvoScimeca, ManuelBonanno, ElenaCassee, Flemming RDemokritou, PhilipPietroiusti, AntonioCampagnolo, Luisa2021-09-212021-09-212021-09-033447959810.1186/s12989-021-00424-zhttp://hdl.handle.net/10029/625274Mouse COCs from pre-ovulatory follicles were cultured in vitro in the presence of various concentrations of two types of TiO2 NPs (JRC NM-103 and NM-104) and four types of ZnO NPs (JRC NM-110, NM-111, and in-house prepared uncoated and SiO2-coated NPs) and the organization of a muco-elastic extracellular matrix by cumulus cells during the process named cumulus expansion was investigated.en© 2021. The Author(s).Cumulus cellsCumulus expansionExtracellular matrixOocyteSilicaTitanium dioxide nanoparticlesZinc oxide nanoparticlesSilica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion.Article1743-8977Part Fibre Toxicol 2021; 18(1):33