Edlow, Andrea GGuedj, FaycalSverdlov, DeannaPennings, Jeroen L ABianchi, Diana W2020-08-162020-08-162019-01-011662-45483192050210.3389/fnins.2019.01335http://hdl.handle.net/10029/624091Throughout pregnancy and lactation, female C57Bl/6J mice were fed one of two standard, commercially available chow diets (pellet versus powder). The powdered chow diet was relatively deficient in micronutrients and enriched for carbohydrates and n-3 long-chain polyunsaturated fatty acids compared to the pelleted chow. RNA was extracted from embryonic day 15.5 forebrains and hybridized to whole genome expression microarrays (N = 5/maternal diet group). Functional analyses of significantly differentially expressed fetal brain genes were performed using Ingenuity Pathways Analysis and Gene Set Enrichment Analysis. Neonatal behavior was assessed using a validated scale (N = 62 pellet-exposed and 31 powder-exposed). Hippocampal learning, locomotor behavior, and motor coordination were assessed in a subset of adults using fear conditioning, open field testing, and Rotarod tests (N = 16 pellet-exposed, 14 powder-exposed).encoordinationfatty acidfetal brainmaternal dietmicronutrientsensorystrengthtranscriptomeArticleFront Neurosci 2019; 13:1335