Seyed Khoei, NazlisadatJenab, MazdaMurphy, NeilBanbury, Barbara LCarreras-Torres, RobertViallon, VivianKühn, TilmanBueno-de-Mesquita, BasAleksandrova, KrasimiraCross, Amanda JWeiderpass, ElisabeteStepien, MagdalenaBulmer, AndrewTjønneland, AnneBoutron-Ruault, Marie-ChristineSeveri, GianlucaCarbonnel, FranckKatzke, VerenaBoeing, HeinerBergmann, Manuela MTrichopoulou, AntoniaKarakatsani, AnnaMartimianaki, GeorgiaPalli, DomenicoTagliabue, GiovannaPanico, SalvatoreTumino, RosarioSacerdote, CarlottaSkeie, GuriMerino, SusanaBonet, CatalinaRodríguez-Barranco, MiguelGil, LeireChirlaque, Maria-DoloresArdanaz, EvaMyte, RobinHultdin, JohanPerez-Cornago, AuroraAune, DagfinnTsilidis, Konstantinos KAlbanes, DemetriusBaron, John ABerndt, Sonja IBézieau, StéphaneBrenner, HermannCampbell, Peter TCasey, GrahamChan, Andrew TChang-Claude, JennyChanock, Stephen JCotterchio, MichelleGallinger, StevenGruber, Stephen BHaile, Robert WHampe, JochenHoffmeister, MichaelHopper, John LHsu, LiHuyghe, Jeroen RJenkins, Mark AJoshi, Amit DKampman, EllenLarsson, Susanna CLe Marchand, LoicLi, Christopher ILi, LiLindblom, AnnikaLindor, Noralane MMartín, VicenteMoreno, VictorNewcomb, Polly AOffit, KennethOgino, ShujiParfrey, Patrick SPharoah, Paul D PRennert, GadSakoda, Lori CSchafmayer, ClemensSchmit, Stephanie LSchoen, Robert ESlattery, Martha LThibodeau, Stephen NUlrich, Cornelia Mvan Duijnhoven, Franzel J BWeigl, KorbinianWeinstein, Stephanie JWhite, EmilyWolk, AlicjaWoods, Michael OWu, Anna HZhang, XuehongFerrari, PietroAnton, GabrielePeters, AnnettePeters, UlrikeGunter, Marc JWagner, Karl-HeinzFreisling, Heinz2020-09-272020-09-272020-09-031741-70153287863110.1186/s12916-020-01703-whttp://hdl.handle.net/10029/624378In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10-8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study.enAnti-oxidantsBilirubinCancerColorectal cancerMendelian randomization analysisArticleBMC Medicine 2020; 18(1):229