Baudin, ClémenceLefèvre, MarieBabisch, WolfgangCadum, EnnioChampelovier, PatriciaDimakopoulou, KonstantinaHouthuijs, DannyLambert, JacquesLaumon, BernardPershagen, GöranStansfeld, StephenVelonaki, VenetiaHansell, Anna LEvrard, Anne-Sophie2021-02-262021-02-262021-02-053354665510.1186/s12889-021-10280-3http://hdl.handle.net/10029/624704A significant association was found between aircraft noise levels at night and antihypertensive medication only in the UK (OR = 1.43, 95%CI 1.19-1.73 for a 10 dB(A)-increase in Lnight). No association was found with other medications. Aircraft noise annoyance was significantly associated with the use of antihypertensive medication (OR = 1.33, 95%CI 1.14-1.56), anxiolytics (OR = 1.48, 95%CI 1.08-2.05), hypnotics and sedatives (OR = 1.60, 95%CI 1.07-2.39), and antasthmatics (OR = 1.44, 95%CI 1.07-1.96), with no difference between countries. Noise sensitivity was significantly associated with almost all medications, with the exception of the use of antasthmatics, showing an increase in ORs with the level of noise sensitivity, with differences in ORs among countries only for the use of antihypertensive medication. The results also suggested a mediating role of aircraft noise annoyance and a modifying role of both aircraft noise annoyance and noise sensitivity in the association between aircraft noise levels and medication use.enAircraft noise annoyanceAircraft noise exposureMedication useNoise sensitivityArticle1471-2458BMC Public Health 2021; 21(1):300