Vaal MABreedijk IDekker MPMout HCAKramers PGNRoghair CJ2017-02-201992-12-31Daphnia magna is used as a model organism to study the consequences of the impact of mutagenic chemicals to natural populations. Adult daphnids were exposed to a mutagenic test compound to test whether their offspring showed effects of induced mutations at exposure levels lower than the No Observed Effect Concentration for growth and reproduction. Life-history parameters were used as test parameters. A concentration-related toxic effect to reproduction could be measured reproducibly in the exposed adult daphnids. However, no indication of a mutagenic effect could be detected in their offspring. This may have been due to the inadequateness of the system to detect induced genetic change.<br>38 pnl07mutageniteittoxische stoffenecotoxicologievoortplantingdosis-effectrelatieneltoetsorganismewatervlooienmutagenicitytoxic substancesecotoxicologyreproductiondose effect relationnelmonitoring organismsdaphnialife-history parametersMutagene stoffen en risico's voor natuurlijke populaties. Onderzoek met Daphnia magna als modelorganisme. II. Experimenten met een mutagene stof[Mutagenic substances and natural populations at risk. Research with Daphnia magna as a model organism. II. Experiments with a mutagenic substance.]Report2017-02-20