Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.

Van Der Ven, Leo T MVan Ommeren, PaulZwart, Edwin PGremmer, Eric RHodemaekers, Hennie MHeusinkveld, Harm Jvan Klaveren, Jacob DRorije, Emiel2022-04-122022-04-122022-04-083539480910.1289/EHP9888http://hdl.handle.net/10029/625708Selection of candidate compounds that potentially induce craniofacial malformations was done using in silico methods-structural similarity, molecular docking, and quantitative structure-activity relationships-applied to a database of chemicals relevant for oral exposure in humans via food (EuroMix inventory, n=1,598). A final subselection was made manually to represent different regulatory fields (e.g., food additives, industrial chemicals, plant protection products), different chemical families, and different MOAs.enDose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.Article1552-9924Environmental health perspectives 2022;130(4):47003