Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis.

Ruesen, CarolienChaidir, Lidyavan Laarhoven, ArjanDian, SofiatiGaniem, Ahmad RizalNebenzahl-Guimaraes, HannaHuynen, Martijn AAlisjahbana, BachtiDutilh, Bas Evan Crevel, Reinout2018-02-122018-02-122018Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis. 2018, 19 (1):122 BMC Genomics1471-21642940222210.1186/s12864-018-4498-zhttp://hdl.handle.net/10029/621405Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.enArchived with thanks to BMC genomicsLarge-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis.ArticleBMC Genomics 2018; 19(1):122