van Paassen, Judithvan Dissel, Jaap THiemstra, Pieter SZwaginga, Jaap JanCobbaert, Christa MJuffermans, Nicole Pde Wilde, Rob BStijnen, Theode Jonge, EvertKlautz, Robert JArbous, M Sesmu2019-10-032019-10-032019-09-011752-03713154447510.2217/bmm-2019-0028http://hdl.handle.net/10029/623259Aim: Biomarkers of acute respiratory distress syndrome (ARDS) after cardiac-surgery may help risk-stratification and management. Preoperative single-value proADM increases predictive capacity of scoring-system EuroSCORE. To include the impact of surgery, we aim to assess the predictive value of the perioperative proADM-change on development of ARDS in 40 cardiac-surgery patients. Materials & methods: ProADM was measured in nine sequential blood samples. The Berlin definition of ARDS was used. For data-analyses, a multivariate model of EuroSCORE and perioperative proADM-change, linear mixed models and logistic regression were used. Results: Perioperative proADM-change was associated with ARDS after cardiac-surgery, and it was superior to EuroSCORE. A perioperative proADM-change >1.5 nmol/l could predict ARDS. Conclusion: Predicting post-surgery ARDS with perioperative proADM-change enables clinicians to intensify lung-protective interventions and individualized fluid therapy to minimize secondary injury.eninfo:eu-repo/semantics/closedAccessARDSProADMbiomarkercardiac surgeryclinical scoring systemintensive careoutcomepredictionArticleBiomark Med 2019; 13(13):1081-91