Danchuk, Sarah NSolomon, Ori EKohl, Thomas AndreasDreyer, ViolaBarilar, IvanUtpatel, ChristianNiemann, StefanSoolingen, Dick vanAnthony, Richardvan Ingen, JakkoMichael, Joy SBehr, Marcel A2024-02-052024-02-052024-01-293828661410.1136/thorax-2023-220202http://hdl.handle.net/10029/627278Heteroresistant infections are defined as infections in which a mixture of drug-resistant and drug-susceptible populations are present. In Mycobacterium tuberculosis (M. tb), heteroresistance poses a challenge in diagnosis and has been linked with poor treatment outcomes. We compared the analytical sensitivity of molecular methods, such as GeneXpert and whole genome sequencing (WGS) in detecting heteroresistance when compared with the 'gold standard' phenotypic assay: the agar proportion method (APM).en© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Bacterial InfectionRespiratory InfectionTuberculosisArticle1468-3296Thorax 2024;79(7):670-675