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  • Publication
    Characterization of aggregated exposure to multiple pesticides near agricultural fields: an application of silicone wristbands
    (2025-04-03) Ottenbros, IB; Vermeulen, RCH; Krop, EJM; Beeltje, H; Fuhrimann, S; Figueiredo, DM
    Public health concerns exist regarding pesticide exposure of workers and residents living near agricultural fields. Still, knowledge is limited in part due to the difficulties of assessing cumulative personal exposure to pesticides over time, as well as the total aggregate exposure. Silicone wristbands are a low-cost and non-invasive passive sampling tool to assess exposure to multiple pesticides. In this study, 19 residents living close to flower bulb fields in the Netherlands wore wristbands for an average of 60 days (range: 38–155). 31 different pesticides were quantified in the wristbands via liquid chromatography with tandem mass spectrometry (LC-MS/MS). For interpretation purposes of potential patterns of exposure the pesticides were categorized by their application status: 1) applied during the study period, 2) registered for usage on flower bulbs but not applied during the study period, 3) not applied and not registered. Measured concentrations reflected highly individualized exposure profiles over a long-term measurement period. The minimum number of pesticides that were detected in a wristband was 6, with an average of 19 (maximum: 31). Azoxystrobin, carbendazim and pymetrozine were detected in all wristbands. While carbendazim was not applied during the study period, it was authorized for spraying on bulb fields. No distinction could be made between wristbands with days of wearing, vapor pressure or soil half-life of the pesticides. Using wristbands, we efficiently assessed pesticide mixture exposure profiles. The co-occurrence of pesticides in the wristbands allowed the identification of realistic chemical mixtures in residents living near agricultural fields. This study demonstrates the potential of wristbands to assess a large number of pesticides over an extended period of time independent of the source of exposure. Due to their low-cost and non-invasive nature, wristbands could be applied in larger populations, combined with the ability to detect a large number of pesticides over time, this methodology could be informative for future environmental health, toxicology, and exposome studies, as well as regulators.
  • Publication
    Enterovirus circulation in the WHO European region, 2015–2022: a comparison of data from WHO's three core poliovirus surveillance systems and the European Non-Polio Enterovirus Network (ENPEN)
    (2025-04-11) Harvala, Heli; Johannesen, Caroline K; Benschop, Kimberley SM; Saxentoff, Eugene V; Huseynov, Shahin; Hagan, José E; Fischer, Thea K
    Background While the association of polioviruses with paralytic disease is well-documented and closely monitored via the Global Polio Eradication initiative, monitoring of the circulation and role of other non-polio enteroviruses in paralytic and non-paralytic disease has not received the same priority. We have assessed assess the role and potential effectiveness of the current enterovirus surveillance systems in the final stages of polio eradication. Methods We compared data on enterovirus circulation and clinical associations reported to the World Health Organization (WHO) Regional Office for Europe via the acute flaccid paralysis (AFP), clinical enterovirus, and environmental surveillance systems along with that collected by the European Non-Polio Enterovirus Network (ENPEN), 2015–2022. Findings This 8-year study analysed data from 63,659 samples from diagnosed enterovirus infections reported by 48 European countries, of which 27,699 were successfully typed (43.5%). This revealed the circulation of 67 individual enterovirus types primarily reported via ENPEN (85%; 19,712/23,220), whereas most poliovirus infections were reported via WHO (99.9%; 4484/4489). Only 20% of non-polio enterovirus positive AFP cases reported to WHO were successfully typed (105/544). Clinical data linked to these cases underscored the severity of paralytic non-polio enterovirus infections with 12 deaths compared to three deaths caused by poliovirus infections during the same study period. Interpretation The study documents non-polio enterovirus infections as a frequent cause of paralysis in Europe. Implementation of standardized monitoring and reporting of all enteroviruses identified from severely ill patients, including those with paralysis, would enhance our understanding of the burden of non-polio enterovirus infections without compromising poliovirus surveillance.
  • Publication
    Safe-by-design assessment of an SiO2@ZnO multi-component nanomaterial used in construction
    (2024-10-23) Brunelli, A; Serrano-Lotina, A; Bañares, MA; Alcolea-Rodriguez, V; Blosi, M; Costa, A; Ortelli, S; Peijnenburg, W; Fito, C; Fernandez, EG; Hermosilla, JS; Soeteman-Hernández, LG; Garmendia Aguirre, I; Rauscher, H; Murphy, F; Stone, V; Balbuena, J; Cormano, JML; Pizzol, L; Hristozov, D; Marcominia, A; Badetti, E
    Safety aspects of chemicals/materials are transversal in all sustainability dimensions, representing a pillar at the early innovation stages of the European Commission's “safe and sustainable by design” (SSbD) framework for chemicals and materials. The first three of the five SSbD framework steps cover different safety aspects, namely, hazard assessment based on intrinsic properties (step 1), occupational health and safety (including exposure) assessment during the production/processing phase (step 2) and exposure in the final application phase (step 3). The goal of this work was to identify a set of characterization tools/procedures to support the operationalization of the first three safety steps in multi-component nanomaterials (MCNMs), applying the findings to an SiO2 core–ZnO shell MCNM. The safety of this MCNM, which is used as an additive to silicate/calcium hydroxide mortar to improve air quality through photocatalytic NOx removal, was investigated from different perspectives along its value chain. Existing and newly generated data on its hazard profile were collected, the exposure of workers during its synthesis was assessed, and potential exposure to hazardous substances during its final application phase was investigated. In step 1, physico-chemical properties, hazard classification and cytotoxicity assays were considered. In step 2, a three-tiered established methodology for evaluating occupational exposure assessment was performed. Lastly, in step 3, the release of inorganic substances from MCNM-based mortars in the final application phase was investigated. Safety assessment according to the SSbD framework was performed by selecting tools and procedures suitable for application in the early innovation stage, resulting in a preliminary hazard assessment of MCNMs and a suggestion for redesigning a step in the process.
  • Publication
    Protection of water resources from agricultural pressures: Embracing different knowledge domains in governance approaches
    Wuijts, Susanne; Graversgaard, Morten; van den Brink, Cors; Boekhold, Sandra; Sundnes, Frode; Farrow, Luke; Surdyk, Nicolas; Cvejic, Rozalija; Tegner Anker, Helle; Belinskij, Antti; van Rijswick, Marleen
    The remediation of nitrate and pesticide pollution from agriculture in drinking water resources has manifested itself as a complex and multifaceted challenge in Europe and in other continents. Addressing agricultural pollution in water resources requires cross sectoral approaches. The EU Water Framework Directive aims to build bridges among these sectors, but the often sectoral implementation by Member States prevents its potential from being fully explored. This study aims to contribute to the body of interdis ciplinary knowledge on the driving forces towards water quality improvement from agri cultural pollution by case study research in five European countries in an interdisciplinary setting. The cases have shown that the added value of voluntary practices is considerable for creating shared ambitions but limited for actual water quality improvement. Imple mentation of strategies should be supported by practical guidance and monitoring of out comes that enables compliance testing and refines simulation models for the formulation of follow-up actions. Dynamic interactions among the knowledge domains, for example, social-economic context, the legal framework, and the state of the water system, help to identify necessary actions at the different stages of the policy cycle. Especially in the implementation, monitoring, evaluation, and adaptation stage of the policy cycle, there is a need for further studies in order to improve effectiveness, for example on the role of monitoring and evaluation, licensing, and the issue of scale in cross-sectoral approaches.
  • Publication
    Residents' perceptions of urban densification and health - a systems dynamics approach
    (2025-04-21) Barsties, Lisa S; Ruijsbroek, Annemarie; Beenackers, Mariëlle A; Luijben, Guus; van den Berg, Saskia W
    Little is known about residents' perceptions of urban densification and its impact on health. A participatory systems dynamics approach can help to understand residents' perspective on the complex system of interacting factors underlying urban densification and health.

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