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Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.
Fregonese, Federica Ahuja, Shama D Akkerman, Onno W Arakaki-Sanchez, Denise Ayakaka, Irene Baghaei, Parvaneh Bang, Didi Bastos, Mayara Benedetti, Andrea Bonnet, Maryline
Fregonese, Federica
Ahuja, Shama D
Akkerman, Onno W
Arakaki-Sanchez, Denise
Ayakaka, Irene
Baghaei, Parvaneh
Bang, Didi
Bastos, Mayara
Benedetti, Andrea
Bonnet, Maryline
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-04
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.
Translated Title
Published in
Lancet Respir Med 2018; 6(4):265-75
Abstract
Isoniazid-resistant, rifampicin-susceptible (INH-R) tuberculosis is the most common form of drug resistance, and is associated with failure, relapse, and acquired rifampicin resistance if treated with first-line anti-tuberculosis drugs. The aim of the study was to compare success, mortality, and acquired rifampicin resistance in patients with INH-R pulmonary tuberculosis given different durations of rifampicin, ethambutol, and pyrazinamide (REZ); a fluoroquinolone plus 6 months or more of REZ; and streptomycin plus a core regimen of REZ.