Respiratory syncytial virus (RSV) infects primary neonatal and adult natural killer cells and affects their anti-viral effector function.
van Erp, Elisabeth A Feyaerts, Dorien Duijst, Maxime Mulder, H Lie Wicht, Oliver Luytjes, Willem Ferwerda, Gerben van Kasteren, Puck B
van Erp, Elisabeth A
Feyaerts, Dorien
Duijst, Maxime
Mulder, H Lie
Wicht, Oliver
Luytjes, Willem
Ferwerda, Gerben
van Kasteren, Puck B
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-09-25
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Respiratory syncytial virus (RSV) infects primary neonatal and adult natural killer cells and affects their anti-viral effector function.
Translated Title
Published in
J Infect Dis 2019; 219(5):723-33
Abstract
Respiratory syncytial virus (RSV) is a major cause of severe acute lower respiratory tract infections in infants. Natural killer (NK) cells are important anti-viral effector cells that likely encounter RSV in the presence of virus-specific (maternal) antibodies. Since NK cells potentially contribute to immunopathology, we investigated whether RSV affects their anti-viral effector functions.