Show simple item record

dc.contributor.authorKlein, Alison P
dc.contributor.authorWolpin, Brian M
dc.contributor.authorRisch, Harvey A
dc.contributor.authorStolzenberg-Solomon, Rachael Z
dc.contributor.authorMocci, Evelina
dc.contributor.authorZhang, Mingfeng
dc.contributor.authorCanzian, Federico
dc.contributor.authorChilds, Erica J
dc.contributor.authorHoskins, Jason W
dc.contributor.authorJermusyk, Ashley
dc.contributor.authorZhong, Jun
dc.contributor.authorSund, Malin
dc.contributor.authorTalar-Wojnarowska, Renata
dc.contributor.authorTavano, Francesca
dc.contributor.authorThornquist, Mark D
dc.contributor.authorTobias, Geoffrey S
dc.contributor.authorVan Den Eeden, Stephen K
dc.contributor.authorVashist, Yogesh
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorVodicka, Pavel
dc.contributor.authorWactawski-Wende, Jean
dc.contributor.authorChen, Fei
dc.contributor.authorWang, Zhaoming
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorWhite, Emily
dc.contributor.authorYu, Herbert
dc.contributor.authorYu, Kai
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorZheng, Wei
dc.contributor.authorKraft, Peter
dc.contributor.authorLi, Donghui
dc.contributor.authorChanock, Stephen
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorObazee, Ofure
dc.contributor.authorPetersen, Gloria M
dc.contributor.authorAmundadottir, Laufey T
dc.contributor.authorAndreotti, Gabriella
dc.contributor.authorArslan, Alan A
dc.contributor.authorBabic, Ana
dc.contributor.authorBamlet, William R
dc.contributor.authorBeane-Freeman, Laura
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorBlackford, Amanda
dc.contributor.authorBorges, Michael
dc.contributor.authorBorgida, Ayelet
dc.contributor.authorBracci, Paige M
dc.contributor.authorBrais, Lauren
dc.contributor.authorBrennan, Paul
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorBuring, Julie
dc.contributor.authorCampa, Daniele
dc.contributor.authorCapurso, Gabriele
dc.contributor.authorCavestro, Giulia Martina
dc.contributor.authorChaffee, Kari G
dc.contributor.authorChung, Charles C
dc.contributor.authorCleary, Sean
dc.contributor.authorCotterchio, Michelle
dc.contributor.authorDijk, Frederike
dc.contributor.authorDuell, Eric J
dc.contributor.authorForetova, Lenka
dc.contributor.authorFuchs, Charles
dc.contributor.authorFunel, Niccola
dc.contributor.authorGallinger, Steven
dc.contributor.authorM Gaziano, J Michael
dc.contributor.authorGazouli, Maria
dc.contributor.authorGiles, Graham G
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGoggins, Michael
dc.contributor.authorGoodman, Gary E
dc.contributor.authorGoodman, Phyllis J
dc.contributor.authorHackert, Thilo
dc.contributor.authorHaiman, Christopher
dc.contributor.authorHartge, Patricia
dc.contributor.authorHasan, Manal
dc.contributor.authorHegyi, Peter
dc.contributor.authorHelzlsouer, Kathy J
dc.contributor.authorHerman, Joseph
dc.contributor.authorHolcatova, Ivana
dc.contributor.authorHolly, Elizabeth A
dc.contributor.authorHoover, Robert
dc.contributor.authorHung, Rayjean J
dc.contributor.authorJacobs, Eric J
dc.contributor.authorJamroziak, Krzysztof
dc.contributor.authorJanout, Vladimir
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKlein, Eric A
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorKooperberg, Charles
dc.contributor.authorKulke, Matthew H
dc.contributor.authorKupcinskas, Juozas
dc.contributor.authorKurtz, Robert J
dc.contributor.authorLaheru, Daniel
dc.contributor.authorLandi, Stefano
dc.contributor.authorLawlor, Rita T
dc.contributor.authorLee, I-Min
dc.contributor.authorLeMarchand, Loic
dc.contributor.authorLu, Lingeng
dc.contributor.authorMalats, Núria
dc.contributor.authorMambrini, Andrea
dc.contributor.authorMannisto, Satu
dc.contributor.authorMilne, Roger L
dc.contributor.authorMohelníková-Duchoňová, Beatrice
dc.contributor.authorNeale, Rachel E
dc.contributor.authorNeoptolemos, John P
dc.contributor.authorOberg, Ann L
dc.contributor.authorOlson, Sara H
dc.contributor.authorOrlow, Irene
dc.contributor.authorPasquali, Claudio
dc.contributor.authorPatel, Alpa V
dc.contributor.authorPeters, Ulrike
dc.contributor.authorPezzilli, Raffaele
dc.contributor.authorPorta, Miquel
dc.contributor.authorReal, Francisco X
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorSesso, Howard D
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorSilverman, Debra
dc.contributor.authorSmith, Jill P
dc.contributor.authorSoucek, Pavel
dc.date.accessioned2018-02-12T12:43:29Z
dc.date.available2018-02-12T12:43:29Z
dc.date.issued2018-02-08
dc.identifier.citationGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. 2018, 9 (1):556 Nat Communen
dc.identifier.issn2041-1723
dc.identifier.pmid29422604
dc.identifier.doi10.1038/s41467-018-02942-5
dc.identifier.urihttp://hdl.handle.net/10029/621401
dc.description.abstractIn 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
dc.language.isoenen
dc.titleGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.en
dc.typeArticleen
dc.identifier.journalNat Commun 2018; 9(1):556en
html.description.abstractIn 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.


This item appears in the following Collection(s)

Show simple item record