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dc.contributor.authorvan Erp, Elisabeth A
dc.contributor.authorLakerveld, Anke J
dc.contributor.authorde Graaf, Erik
dc.contributor.authorLarsen, Mads D
dc.contributor.authorSchepp, Rutger M
dc.contributor.authorHipgrave Ederveen, Agnes L
dc.contributor.authorAhout, Inge Ml
dc.contributor.authorde Haan, Cornelis Am
dc.contributor.authorWuhrer, Manfred
dc.contributor.authorLuytjes, Willem
dc.contributor.authorFerwerda, Gerben
dc.contributor.authorVidarsson, Gestur
dc.contributor.authorvan Kasteren, Puck B
dc.date.accessioned2020-05-24T19:51:48Z
dc.date.available2020-05-24T19:51:48Z
dc.date.issued2020-01-01
dc.identifier.issn2050-0068
dc.identifier.pmid32099650
dc.identifier.doi10.1002/cti2.1112
dc.identifier.urihttp://hdl.handle.net/10029/623778
dc.description.abstractWe found that RSV-specific maternal antibodies activate NK cells in vitro. While concentrations of RSV-specific antibodies did not differ between cases and controls, antibodies from infants hospitalised for severe respiratory infections (RSV and/or other) induced significantly less NK cell interferon-γ production than those from uninfected controls. Furthermore, NK cell activation correlated with Fc-fucosylation of RSV-specific antibodies, but their glycosylation status did not significantly differ between cases and controls.en_US
dc.language.isoenen_US
dc.subjectFc‐mediated effector functionsen_US
dc.subjectNK cellen_US
dc.subjectantibody‐dependent cell‐mediated cytotoxicityen_US
dc.subjectfucosylationen_US
dc.subjectinterferon‐gammaen_US
dc.subjectrespiratory syncytial virusen_US
dc.titleNatural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation.en_US
dc.typeArticleen_US
dc.identifier.journalClin Transl Immunology 2020; 9(2):e1112en_US
dc.source.journaltitleClinical & translational immunology


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