Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation.
dc.contributor.author | van Erp, Elisabeth A | |
dc.contributor.author | Lakerveld, Anke J | |
dc.contributor.author | de Graaf, Erik | |
dc.contributor.author | Larsen, Mads D | |
dc.contributor.author | Schepp, Rutger M | |
dc.contributor.author | Hipgrave Ederveen, Agnes L | |
dc.contributor.author | Ahout, Inge Ml | |
dc.contributor.author | de Haan, Cornelis Am | |
dc.contributor.author | Wuhrer, Manfred | |
dc.contributor.author | Luytjes, Willem | |
dc.contributor.author | Ferwerda, Gerben | |
dc.contributor.author | Vidarsson, Gestur | |
dc.contributor.author | van Kasteren, Puck B | |
dc.date.accessioned | 2020-05-24T19:51:48Z | |
dc.date.available | 2020-05-24T19:51:48Z | |
dc.date.issued | 2020-01-01 | |
dc.identifier.issn | 2050-0068 | |
dc.identifier.pmid | 32099650 | |
dc.identifier.doi | 10.1002/cti2.1112 | |
dc.identifier.uri | http://hdl.handle.net/10029/623778 | |
dc.description.abstract | We found that RSV-specific maternal antibodies activate NK cells in vitro. While concentrations of RSV-specific antibodies did not differ between cases and controls, antibodies from infants hospitalised for severe respiratory infections (RSV and/or other) induced significantly less NK cell interferon-γ production than those from uninfected controls. Furthermore, NK cell activation correlated with Fc-fucosylation of RSV-specific antibodies, but their glycosylation status did not significantly differ between cases and controls. | en_US |
dc.language.iso | en | en_US |
dc.subject | Fc‐mediated effector functions | en_US |
dc.subject | NK cell | en_US |
dc.subject | antibody‐dependent cell‐mediated cytotoxicity | en_US |
dc.subject | fucosylation | en_US |
dc.subject | interferon‐gamma | en_US |
dc.subject | respiratory syncytial virus | en_US |
dc.title | Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation. | en_US |
dc.type | Article | en_US |
dc.identifier.journal | Clin Transl Immunology 2020; 9(2):e1112 | en_US |
dc.source.journaltitle | Clinical & translational immunology |