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dc.contributor.authorde Vries, Rory D
dc.contributor.authorde Jong, Alwin
dc.contributor.authorVerburgh, R Joyce
dc.contributor.authorSauerhering, Lucie
dc.contributor.authorvan Nierop, Gijsbert P
dc.contributor.authorvan Binnendijk, Robert S
dc.contributor.authorOsterhaus, Albert D M E
dc.contributor.authorMaisner, Andrea
dc.contributor.authorKoopmans, Marion P G
dc.contributor.authorde Swart, Rik L
dc.date.accessioned2020-07-17T08:40:56Z
dc.date.available2020-07-17T08:40:56Z
dc.date.issued2020-07-07
dc.identifier.issn2150-7511
dc.identifier.pmid32636246
dc.identifier.doi10.1128/mBio.00972-20
dc.identifier.urihttp://hdl.handle.net/10029/623972
dc.description.abstractHumans are infected with paramyxoviruses of different genera early in life, which induce cytotoxic T cells that may recognize conserved epitopes. This raises the question of whether cross-reactive T cells induced by antecedent paramyxovirus infections provide partial protection against highly lethal zoonotic Nipah virus infections. By characterizing a measles virus-specific but paramyxovirus cross-reactive human T cell clone, we discovered a highly conserved HLA-B*1501-restricted T cell epitope in the fusion protein. Using peptides, tetramers, and single cell sorting, we isolated a parainfluenza virus-specific T cell clone from a healthy adult and showed that both clones cleared Nipah virus-infected cells. We identified multiple conserved hot spots in paramyxovirus proteomes that contain other potentially cross-reactive epitopes. Our data suggest that, depending on HLA haplotype and history of paramyxovirus exposures, humans may have cross-reactive T cells that provide protection against Nipah virus. The effect of preferential boosting of these cross-reactive epitopes needs to be further studied in light of paramyxovirus vaccination studies.IMPORTANCE Humans encounter multiple paramyxoviruses early in life. This study shows that infection with common paramyxoviruses can induce T cells cross-reactive with the highly pathogenic Nipah virus. This demonstrates that the combination of paramyxovirus infection history and HLA haplotype affects immunity to phylogenetically related zoonotic paramyxoviruses.en_US
dc.language.isoenen_US
dc.subjectNipah virusen_US
dc.subjectT cellsen_US
dc.subjecthuman parainfluenza virusen_US
dc.subjectmeasles virusen_US
dc.subjectparamyxovirusen_US
dc.titleHuman Paramyxovirus Infections Induce T Cells That Cross-React with Zoonotic Henipaviruses.en_US
dc.typeArticleen_US
dc.identifier.journalMbio 2020; 11(4):pii.e00972-20en_US
dc.source.journaltitlemBio


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