A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections.
Koenen, Mischa H Bosma, Madeleen Roorda, Udo A Wopereis, Fabiënne My Roos, Anja van der Vries, Erhard Bogaert, Debby Sanders, Elisabeth Am Boes, Marianne Heidema, Jojanneke
Koenen, Mischa H
Bosma, Madeleen
Roorda, Udo A
Wopereis, Fabiënne My
Roos, Anja
van der Vries, Erhard
Bogaert, Debby
Sanders, Elisabeth Am
Boes, Marianne
Heidema, Jojanneke
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Open Access
Type
Article
Language
en
Date of publication
2021-10-29
Year of publication
Research Projects
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Journal Issue
Title
A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections.
Translated Title
Published in
Clin Transl Immunology 2021;10(11):e1344
Abstract
We developed reference values for IgA for seven age groups and five different laboratory assays. Using these reference values, IgA measurements from 417 cases and 224 controls were standardised to compare groups. In children aged 2 years and older, IgA deficiency was observed in 2.9% (7/242) of cases and 0% (0/189) of controls (P = 0.02).