Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis

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dc.contributor.authorBeran, Magdalena
dc.contributor.authorJansen, Willemijn J
dc.contributor.authorOomens, Julie E
dc.contributor.authorMoonen, Justine EF
dc.contributor.authorSlagboom, P Eline
dc.contributor.authorHuisman, Martijn
dc.contributor.authorKok, Almar AL
dc.contributor.authorNooyens, Astrid CJ
dc.contributor.authorVerschuren, Wilhelmina Maria Monique
dc.contributor.authorStehouwer, Coen DA
dc.contributor.authorSchalkwijk, Casper
dc.contributor.authorKöhler, Sebastian
dc.contributor.authorBeekman, Marian
dc.contributor.authorSlagboom, Pieternella Eline
dc.contributor.authorWolters, Frank J
dc.contributor.authorIkram, M Arfan
dc.contributor.authorVallerga, Costanza L
dc.contributor.authorvan Meurs, Joyce BJ
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorVonk, Jet MJ
dc.contributor.authorGeerlings, Mirjam I
dc.contributor.authorvan Sloten, Thomas T
dc.contributor.authorSchram, Miranda T
dc.date.accessioned2024-12-31T12:26:35Z
dc.date.available2024-12-31T12:26:35Z
dc.date.issued2024-10-20
dc.description.abstractThis study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline.
dc.description.abstractData from 9414 individuals from eight Dutch cohorts were included (Ø  age-range: 57-93 years). Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses.
dc.description.abstractA higher endothelial dysfunction composite score was cross-sectionally associated with worse performance on executive function, processing speed, delayed memory, and attention, but not immediate memory or language (pooled β-range: -0.04, -0.02). We found no association with change in cognition over time.
dc.description.abstractThis comprehensive two-step, individual participant data (IPD) meta-analysis showed a small, consistent cross-sectional association between endothelial dysfunction and worse cognitive performance across multiple domains but no support for a longitudinal association.
dc.description.abstractPrior evidence on endothelial dysfunction (ED) biomarkers and cognition is conflicting. This two-step, individual participant data (IPD) meta-analysis used data from eight Dutch cohorts. ED was consistently associated with concurrent cognition. ED was not associated with a change in cognition over time. The association of ED with current cognition may be generic.
dc.identifier.doi10.1002/alz.14272
dc.identifier.journalAlzheimers Dement 2024; 20(12):8402-8411
dc.identifier.pmid39428719
dc.identifier.urihttps://rivm.openrepository.com/handle/10029/627959
dc.language.isoen
dc.rights© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
dc.source.beginpage8402
dc.source.countryUnited States
dc.source.endpage8411
dc.source.issue12
dc.source.journaltitleAlzheimer's & dementia : the journal of the Alzheimer's Association
dc.source.volume20
dc.subjectbiomarkers
dc.subjectcognition
dc.subjectcohort
dc.subjectendothelial dysfunction
dc.subjectmeta‐analysis
dc.titleBiomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis
dc.typeArticle
dspace.entity.typePublication
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