Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: A population-based cohort study.
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Open Access
Type
Article
Language
en
Date
2024-07-02
Research Projects
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Journal Issue
Title
Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: A population-based cohort study.
Translated Title
Published in
Environ Res 2024;259:119552
Abstract
A Dutch national cohort of 10.8 million adults aged ≥30 years was followed from 2013 until 2019. Annual average concentrations of air pollutants (ultra-fine particles (UFP), nitrogen dioxide (NO2), fine particles (PM2.5 and PM10) and elemental carbon (EC)) were estimated at the home address at baseline, using land-use regression models. The outcome variables were mortality due to amyotrophic lateral sclerosis (ALS), Parkinson's disease, non-vascular dementia, Alzheimer's disease, and multiple sclerosis (MS). Hazard ratios (HR) were estimated using Cox models, adjusting for individual and area-level socio-economic status covariates.