Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts.

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dc.contributor.authorContreras, Zuelma A
dc.contributor.authorChen, Zhanghua
dc.contributor.authorRoumeliotaki, Theano
dc.contributor.authorAnnesi-Maesano, Isabella
dc.contributor.authorBaïz, Nour
dc.contributor.authorvon Berg, Andrea
dc.contributor.authorBergström, Anna
dc.contributor.authorCrozier, Sarah
dc.contributor.authorDuijts, Liesbeth
dc.contributor.authorEkström, Sandra
dc.contributor.authorEller, Esben
dc.contributor.authorFantini, Maria P
dc.contributor.authorKjaer, Henrik Fomsgaard
dc.contributor.authorForastiere, Francesco
dc.contributor.authorGerhard, Beatrix
dc.contributor.authorGori, Davide
dc.contributor.authorHarskamp-van Ginkel, Margreet W
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorIñiguez, Carmen
dc.contributor.authorInskip, Hazel
dc.contributor.authorKeil, Thomas
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorLau, Susanne
dc.contributor.authorLehmann, Irina
dc.contributor.authorMaier, Dieter
dc.contributor.authorvan Meel, Evelien R
dc.contributor.authorMommers, Monique
dc.contributor.authorMurcia, Mario
dc.contributor.authorPorta, Daniela
dc.contributor.authorSmit, Henriëtte A
dc.contributor.authorStandl, Marie
dc.contributor.authorStratakis, Nikos
dc.contributor.authorSunyer, Jordi
dc.contributor.authorThijs, Carel
dc.contributor.authorTorrent, Maties
dc.contributor.authorVrijkotte, Tanja G M
dc.contributor.authorWijga, Alet H
dc.contributor.authorBerhane, Kiros
dc.contributor.authorGilliland, Frank
dc.contributor.authorChatzi, Leda
dc.date.accessioned2018-10-15T09:01:53Z
dc.date.available2018-10-15T09:01:53Z
dc.date.issued2018-09
dc.description.abstractThe parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
dc.identifier.citationDoes early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. 2018, 52 (3) Eur. Respir. J.en
dc.identifier.doi10.1183/13993003.00504-2018
dc.identifier.issn1399-3003
dc.identifier.journalEur Respir J 2018; 52(3):1800504en
dc.identifier.pmid30209194
dc.identifier.urihttp://hdl.handle.net/10029/622194
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleDoes early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts.en
dc.typeArticleen
dspace.entity.typePublication
html.description.abstractThe parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
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