Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.
Van Der Ven, Leo T M Van Ommeren, Paul Zwart, Edwin P Gremmer, Eric R Hodemaekers, Hennie M Heusinkveld, Harm J van Klaveren, Jacob D Rorije, Emiel
Van Der Ven, Leo T M
Van Ommeren, Paul
Zwart, Edwin P
Gremmer, Eric R
Hodemaekers, Hennie M
Heusinkveld, Harm J
van Klaveren, Jacob D
Rorije, Emiel
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2022-04-08
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.
Translated Title
Published in
Environmental health perspectives 2022;130(4):47003
Abstract
Selection of candidate compounds that potentially induce craniofacial malformations was done using in silico methods-structural similarity, molecular docking, and quantitative structure-activity relationships-applied to a database of chemicals relevant for oral exposure in humans via food (EuroMix inventory, n=1,598). A final subselection was made manually to represent different regulatory fields (e.g., food additives, industrial chemicals, plant protection products), different chemical families, and different MOAs.