Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study
Samson, Leonard Daniël van den Berg, Sara PH Engelfriet, Peter Boots, Annemieke MH Hendriks, Marion de Rond, Lia GH de Zeeuw-Brouwer, Mary-Lène Verschuren, WM Monique Borghans, José AM Buisman, Anne-Marie
Samson, Leonard Daniël
van den Berg, Sara PH
Engelfriet, Peter
Boots, Annemieke MH
Hendriks, Marion
de Rond, Lia GH
de Zeeuw-Brouwer, Mary-Lène
Verschuren, WM Monique
Borghans, José AM
Buisman, Anne-Marie
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Open Access
Type
Article
Language
en
Date of publication
2020-01-01
Year of publication
Research Projects
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Journal Issue
Title
Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study
Translated Title
Published in
Clin Transl Immunol 2020; 9(10):e1193
Abstract
In our study, 136/268 individuals were long-term CMV seropositive and 19 seroconverted during follow-up (seroconversion rate: 0.56%/year). CMV-specific antibody levels increased slightly over time. However, we did not find an association between duration of CMV infection and CMV-specific antibody levels at study endpoint. No clear association between duration of CMV infection and the size and function of the memory T-cell pool was observed. Elevated CMV-specific antibody levels were associated with the prevalence of cardiovascular disease but not with frailty. Age at CMV seroconversion was positively associated with CMV-specific antibody levels, memory CD4+ T-cell numbers and frailty.