External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.
Lamain-de Ruiter, Marije; Kwee, Anneke; Naaktgeboren, Christiana A; Louhanepessy, Rebecca D; De Groot, Inge; Evers, Inge M; Groenendaal, Floris; Hering, Yolanda R; Huisjes, Anjoke J M; Kirpestein, Cornel; Monincx, Wilma M; Schielen, Peter C J I; Van 't Zelfde, Annewil; Van Oirschot, Charlotte M; Vankan-Buitelaar, Simone A; Vonk, Mariska A A W; Wiegers, Therese A; Zwart, Joost J; Moons, Karel G M; Franx, Arie; Koster, Maria P H
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Series / Report no.
Open Access
Type
Article
Language
en
Date
2019-03-20
Research Projects
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Title
External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.
Translated Title
Published in
Hypertens Pregnancy 2019; advance online publication (ahead of print)
Abstract
To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.