Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.

Najjar, Abdulkarim; Punt, Ans; Wambaugh, John; Paini, Alicia; Ellison, Corie; Fragki, Styliani; Bianchi, Enrica; Zhang, Fagen; Westerhout, Joost; Mueller, Dennis; Li, Hequn; Shi, Quan; Gant, Timothy W; Botham, Phil; Bars, Rémi; Piersma, Aldert; van Ravenzwaay, Ben; Kramer, Nynke I

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Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.

Najjar, Abdulkarim; Punt, Ans; Wambaugh, John; Paini, Alicia; Ellison, Corie; Fragki, Styliani; Bianchi, Enrica; Zhang, Fagen; Westerhout, Joost; Mueller, Dennis; Li, Hequn; Shi, Quan; Gant, Timothy W; Botham, Phil; Bars, Rémi; Piersma, Aldert; van Ravenzwaay, Ben; Kramer, Nynke I

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Article

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en

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2022-09-05

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Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.

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Archives of toxicology 2022; 96(12):3407-3419

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.

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