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    Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza.

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    Authors
    Rondy, Marc
    Launay, Odile
    Castilla, Jesus
    Costanzo, Simona
    Puig-Barberà, Joan
    Gefenaite, Giedre
    Larrauri, Amparo
    Rizzo, Caterina
    Pitigoi, Daniela
    Syrjänen, Ritva K
    Machado, Ausenda
    Kurečić Filipović, Sanja
    Krisztina Horváth, Judit
    Paradowska-Stankiewicz, Iwona
    Marbus, Sierk
    Moren, Alain
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    Article
    Language
    en
    
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    Title
    Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza.
    Published in
    Vaccine 2017, 35(34):4298-306
    Publiekssamenvatting
    In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two previous seasons. We recruited 5295 patients over the four seasons, including 465A(H1N1)pdm09, 642A(H3N2), 278 B case-patients and 3910 controls. Among patients unvaccinated in both previous two seasons, current seasonal IVE (pooled across seasons) was 30% (95%CI: -35 to 64), 8% (95%CI: -94 to 56) and 33% (95%CI: -43 to 68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Among patients vaccinated in both previous seasons, current seasonal IVE (pooled across seasons) was -1% (95%CI: -80 to 43), 37% (95%CI: 7-57) and 43% (95%CI: 1-68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that, regardless of patients' recent vaccination history, current seasonal vaccine conferred some protection to vaccinated patients against hospitalisation with influenza A(H3N2) and B. Vaccination of patients already vaccinated in both the past two seasons did not seem to be effective against A(H1N1)pdm09. To better understand the effect of repeated vaccination, engaging in large cohort studies documenting exposures to vaccine and natural infection is needed.
    DOI
    10.1016/j.vaccine.2017.06.088
    PMID
    28709555
    URI
    http://hdl.handle.net/10029/621011
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2017.06.088
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