Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.
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De Saeger, Sarah
De Boevre, Marthe
MetadataShow full item record
TitleHumans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.
Published inSci Rep 2018; 8(1):5255
PubliekssamenvattingFor the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a single bolus of 1 µg/kg body weight of DON and a single bolus of 1 µg/kg body weight of DON-3-glucoside after a washing-out period of two months was administered, and a 24-h urine collection was performed. The urine was analysed for DON, DON-3-glucoside, 3-ADON, 15-ADON, deepoxy-deoxynivalenol (DOM-1), deoxynivalenol-3-glucuronide (DON-3-glucuronide) and deoxynivalenol-15-glucuronide (DON-15-glucuronide). The urinary biomarker-analysis revealed that DON and DON-3-glucoside were rapidly absorbed, distributed, metabolized and excreted. Sixty-four % of the administered DON and 58% of DON-3-glucoside was recovered in the urine collected within 24 h. DON-15-glucuronide was the most prominent urinary biomarker followed by free DON and DON-3-glucuronide. Moreover, correlations among the presence of DON-15-glucuronide and DON-3-glucuronide were observed (within 24 hours (r = 0.61)). The DOM-1 detected in the urine was higher after the DON-3-glucoside administration. The obtained results are imperative to construct a standardized method to estimate DON-intake by means of urinary biomarkers.
- Biomonitoring of Deoxynivalenol and Deoxynivalenol-3-glucoside in Human Volunteers: Renal Excretion Profiles.
- Authors: Mengelers M, Zeilmaker M, Vidal A, De Boevre M, De Saeger S, Hoogenveen R
- Issue date: 2019 Aug 8
- Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs.
- Authors: Nagl V, Woechtl B, Schwartz-Zimmermann HE, Hennig-Pauka I, Moll WD, Adam G, Berthiller F
- Issue date: 2014 Aug 17
- Human biomonitoring of multiple mycotoxins in the Belgian population: Results of the BIOMYCO study.
- Authors: Heyndrickx E, Sioen I, Huybrechts B, Callebaut A, De Henauw S, De Saeger S
- Issue date: 2015 Nov
- Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows.
- Authors: Schwartz-Zimmermann HE, Hametner C, Nagl V, Fiby I, Macheiner L, Winkler J, Dänicke S, Clark E, Pestka JJ, Berthiller F
- Issue date: 2017 Dec
- The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol.
- Authors: Gratz SW, Duncan G, Richardson AJ
- Issue date: 2013 Mar