Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study.
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Authors
Rietman, M LisetSpijkerman, Annemieke M W
Wong, Albert
van Steeg, Harry
Bürkle, Alexander
Moreno-Villanueva, María
Sindlinger, Thilo
Franceschi, Claudio
Grubeck-Loebenstein, Beatrix
Bernhardt, Jürgen
Slagboom, P Eline
Toussaint, Olivier
Debacq-Chainiaux, Florence
Sikora, Ewa
Gonos, Efstathios S
Breusing, Nicolle
Stuetz, Wolfgang
Weber, Daniela
Grune, Tilman
Basso, Andrea
Piacenza, Francesco
Malavolta, Marco
Collino, Sebastiano
Jansen, Eugene H J M
Verschuren, W M Monique
Dollé, Martijn E T
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ArticleLanguage
en
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Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study.Published in
Mech Ageing Dev 2019; 177:135-143Publiekssamenvatting
Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i.e. biomarkers and markers, for the physical, cognitive, and psychological frailty domains. We used univariate (Rank-ANOVA) and multivariate (elastic net) approaches on the RASIG study population (age range: 35-74 years, n = 2220) of the MARK-AGE Study to study up to 331 (bio)markers between individuals with and without frailty for each domain. Biomarkers and markers identified by both approaches were studied further regarding their association with frailty using logistic regression. Univariately, we found lower levels of antioxidants, including β-cryptoxanthin and zeaxanthin, in those who were physically, cognitively or psychologically frail. Additionally, self-reported health was worse in these three frail groups. Multivariately, we observed lower levels of β-cryptoxanthin and zeaxanthin in the cognitively frail. Levels of these carotenoids were inversely associated with the risk of being cognitively frail after adjusting for confounders. Antioxidants and self-reported health are potential (bio)markers to detect persons at risk of becoming frail. The biomarkers identified may indicate the involvement of inflammation in frailty, especially for physical and cognitive frailty.PMID
29719199ae974a485f413a2113503eed53cd6c53
10.1016/j.mad.2018.04.007
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