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    Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study.

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    Authors
    Rietman, M Liset
    Spijkerman, Annemieke M W
    Wong, Albert
    van Steeg, Harry
    Bürkle, Alexander
    Moreno-Villanueva, María
    Sindlinger, Thilo
    Franceschi, Claudio
    Grubeck-Loebenstein, Beatrix
    Bernhardt, Jürgen
    Slagboom, P Eline
    Toussaint, Olivier
    Debacq-Chainiaux, Florence
    Sikora, Ewa
    Gonos, Efstathios S
    Breusing, Nicolle
    Stuetz, Wolfgang
    Weber, Daniela
    Grune, Tilman
    Basso, Andrea
    Piacenza, Francesco
    Malavolta, Marco
    Collino, Sebastiano
    Jansen, Eugene H J M
    Verschuren, W M Monique
    Dollé, Martijn E T
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    Type
    Article
    Language
    en
    
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    Title
    Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study.
    Published in
    Mech Ageing Dev 2019; 177:135-143
    Publiekssamenvatting
    Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i.e. biomarkers and markers, for the physical, cognitive, and psychological frailty domains. We used univariate (Rank-ANOVA) and multivariate (elastic net) approaches on the RASIG study population (age range: 35-74 years, n = 2220) of the MARK-AGE Study to study up to 331 (bio)markers between individuals with and without frailty for each domain. Biomarkers and markers identified by both approaches were studied further regarding their association with frailty using logistic regression. Univariately, we found lower levels of antioxidants, including β-cryptoxanthin and zeaxanthin, in those who were physically, cognitively or psychologically frail. Additionally, self-reported health was worse in these three frail groups. Multivariately, we observed lower levels of β-cryptoxanthin and zeaxanthin in the cognitively frail. Levels of these carotenoids were inversely associated with the risk of being cognitively frail after adjusting for confounders. Antioxidants and self-reported health are potential (bio)markers to detect persons at risk of becoming frail. The biomarkers identified may indicate the involvement of inflammation in frailty, especially for physical and cognitive frailty.
    DOI
    10.1016/j.mad.2018.04.007
    PMID
    29719199
    URI
    http://hdl.handle.net/10029/621921
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.mad.2018.04.007
    Scopus Count
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