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dc.contributor.authorBongaerts, Eva
dc.contributor.authorNawrot, Tim S
dc.contributor.authorWang, Congrong
dc.contributor.authorAmeloot, Marcel
dc.contributor.authorBové, Hannelore
dc.contributor.authorRoeffaers, Maarten Bj
dc.contributor.authorChavatte-Palmer, Pascale
dc.contributor.authorCouturier-Tarrade, Anne
dc.contributor.authorCassee, Flemming R
dc.date.accessioned2023-05-22T09:52:20Z
dc.date.available2023-05-22T09:52:20Z
dc.date.issued2023-05-18
dc.identifier.pmid37202804
dc.identifier.doi10.1186/s12989-023-00531-z
dc.identifier.urihttp://hdl.handle.net/10029/626703
dc.description.abstractAirborne pollution particles have been shown to translocate from the mother's lung to the fetal circulation, but their distribution and internal placental-fetal tissue load remain poorly explored. Here, we investigated the placental-fetal load and distribution of diesel engine exhaust particles during gestation under controlled exposure conditions using a pregnant rabbit model. Pregnant dams were exposed by nose-only inhalation to either clean air (controls) or diluted and filtered diesel engine exhaust (1 mg/m3) for 2 h/day, 5 days/week, from gestational day (GD) 3 to GD27. At GD28, placental and fetal tissues (i.e., heart, kidney, liver, lung and gonads) were collected for biometry and to study the presence of carbon particles (CPs) using white light generation by carbonaceous particles under femtosecond pulsed laser illumination.en_US
dc.language.isoenen_US
dc.rights© 2023. The Author(s).
dc.subjectAirborne pollutionen_US
dc.subjectDiesel exhausten_US
dc.subjectGestational exposureen_US
dc.subjectLabel-free detectionen_US
dc.titlePlacental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust.en_US
dc.typeArticleen_US
dc.identifier.eissn1743-8977
dc.identifier.journalPart Fibre Toxicol 2023;20(1):20en_US
dc.source.journaltitleParticle and fibre toxicology
dc.source.volume20
dc.source.issue1
dc.source.beginpage20
dc.source.endpage
dc.source.countryInternational
dc.source.countryEngland


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