Primary SARS-CoV-2 infection in children and adults results in similar Fc-mediated antibody effector function patterns
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Type
Article
Language
en
Date
2024-07-26
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Title
Primary SARS-CoV-2 infection in children and adults results in similar Fc-mediated antibody effector function patterns
Translated Title
Published in
Clin Transl Immunol 2024; 13(8):e1521
Abstract
Here, we assessed the development of spike S1-specific serum antibody-dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and natural killer cell activation (ADNKA), alongside specific antibody binding concentrations (IgG, IgA and IgM) and IgG avidity in healthy adults (n = 38, 18-56 years) and children (n = 21, 5-16 years) following primary SARS-CoV-2 infection, with a 10-month longitudinal follow-up. Differences between groups were assessed using a nonparametric Kruskal-Wallis test with Dunn's multiple comparisons test.