Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures
dc.contributor.author | Gosens, Ilse | |
dc.contributor.author | Minnema, Jordi | |
dc.contributor.author | Boere, A John F | |
dc.contributor.author | Duistermaat, Evert | |
dc.contributor.author | Fokkens, Paul | |
dc.contributor.author | Vidmar, Janja | |
dc.contributor.author | Löschner, Katrin | |
dc.contributor.author | Bokkers, Bas | |
dc.contributor.author | Costa, Anna L | |
dc.contributor.author | Peters, Ruud JB | |
dc.contributor.author | Delmaar, Christiaan | |
dc.contributor.author | Cassee, Flemming R | |
dc.date.accessioned | 2024-08-23T08:15:57Z | |
dc.date.available | 2024-08-23T08:15:57Z | |
dc.date.issued | 2024-08-14 | |
dc.identifier.pmid | 39143599 | |
dc.identifier.doi | 10.1186/s12989-024-00588-4 | |
dc.identifier.uri | http://hdl.handle.net/10029/627784 | |
dc.description.abstract | Rats were exposed to cerium dioxide (CeO2, 28.4 ± 10.4 nm) and titanium dioxide (TiO2, 21.6 ± 1.5 nm) ENMs in a single nose-only exposure to 20 mg/m3 or a repeated exposure of 2 × 5 days to 5 mg/m3. Different dose levels were obtained by varying the exposure time for 30 min, 2 or 6 h per day. The content of cerium or titanium in three compartments of the lung (tissue, epithelial lining fluid and freely moving cells), mediastinal lymph nodes, liver, spleen, kidney, blood and excreta was measured by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) at various time points post-exposure. As biodistribution is best studied at sub-toxic dose levels, lactate dehydrogenase (LDH), total protein, total cell numbers and differential cell counts were determined in bronchoalveolar lavage fluid (BALF). | en_US |
dc.language.iso | en | en_US |
dc.rights | © 2024. The Author(s). | |
dc.subject | Cerium dioxide NM-212 | en_US |
dc.subject | In vivo | en_US |
dc.subject | Inhalation exposure | en_US |
dc.subject | Lung clearance | en_US |
dc.subject | Physiologically-based kinetic modelling | en_US |
dc.subject | Poorly soluble nanoparticles | en_US |
dc.subject | Tissue distribution | en_US |
dc.subject | Titanium dioxide NM-105 | en_US |
dc.subject | Toxicity | en_US |
dc.title | Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1743-8977 | |
dc.identifier.journal | Part Fibre Toxicol 2024; 21(1):33 | en_US |
dc.source.journaltitle | Particle and fibre toxicology | |
dc.source.volume | 21 | |
dc.source.issue | 1 | |
dc.source.beginpage | 33 | |
dc.source.endpage | ||
dc.source.country | England |