Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells.

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dc.contributor.authorSkuland, Tonje
dc.contributor.authorGrytting, Vegard Sæter
dc.contributor.authorLåg, Marit
dc.contributor.authorJørgensen, Rikke Bræmming
dc.contributor.authorSnilsberg, Brynhild
dc.contributor.authorLeseman, Daan L A C
dc.contributor.authorKubátová, Alena
dc.contributor.authorEmond, Jessica
dc.contributor.authorCassee, Flemming R
dc.contributor.authorHolme, Jørn A
dc.contributor.authorØvrevik, Johan
dc.contributor.authorRefsnes, Magne
dc.date.accessioned2022-07-31T19:21:19Z
dc.date.available2022-07-31T19:21:19Z
dc.date.issued2022-07-04
dc.description.abstractThe pro-inflammatory potency of the PM samples varied between road tunnels and size fractions, but showed more marked responses than for the stone materials used in asphalt of the respective tunnels. In particular, fine samples showed significant increases as low as 25 µg/mL (2.6 µg/cm2) and were more potent than coarse samples, while ultrafine samples showed more variable responses between tunnels, sampling conditions and endpoints. The most marked responses were observed for fine PM sampled during humid road surface conditions. Linear correlation analysis showed that particle-induced cytokine responses were correlated to OC levels, while no correlations were observed for other PM characteristics.en_US
dc.identifier.doi10.1186/s12989-022-00488-5
dc.identifier.eissn1743-8977
dc.identifier.journalPart Fibre Toxicol 2022;19(1):45en_US
dc.identifier.pmid35787286
dc.identifier.urihttp://hdl.handle.net/10029/625928
dc.language.isoenen_US
dc.rights© 2022. The Author(s).
dc.source.beginpage45
dc.source.countryEngland
dc.source.endpage
dc.source.issue1
dc.source.journaltitleParticle and fibre toxicology
dc.source.volume19
dc.subjectCytokinesen_US
dc.subjectEpithelial lung cellsen_US
dc.subjectMineral particlesen_US
dc.subjectOrganic carbonen_US
dc.subjectOxidative potentialen_US
dc.subjectStone particlesen_US
dc.subjectUrban air particulate matteren_US
dc.titleRoad tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dspace.entity.typePublication
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