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Nadelige gezondheidseffecten en ziekten veroorzaakt door blootstelling aan hexamethyleen di-isocyanaat (HDI). Actualisatie van de wetenschappelijke literatuur
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Series / Report no.
RIVM rapport 2021-0178
Open Access
Type
Report
Language
nl
Date
2022-02-02
Research Projects
Organizational Units
Journal Issue
Title
Nadelige gezondheidseffecten en ziekten veroorzaakt door blootstelling aan hexamethyleen di-isocyanaat (HDI). Actualisatie van de wetenschappelijke literatuur
Translated Title
Adverse health effects and diseases caused by exposure to hexamethylene di-isocyanate (HDI). Update of the scientific literature
Published in
Abstract
Tussen 1984 en 2006 hebben werknemers van Defensie op de zogenoemde POMS-locaties (Prepositioned Organizational Materiel Storage) in Nederland Amerikaans materieel onderhouden. Zij hebben daar onder andere gewerkt met CARC (Chemical Agent Resistant Coating), een beschermende toplaag voor legervoertuigen.
Tijdens onderhoudswerk zijn werknemers mogelijk blootgesteld aan componenten in CARC. Hexamethyleen di-isocyanaat, afgekort HDI, is een belangrijk bestanddeel van CARC en heeft schadelijke eigenschappen. De kans om ziek te worden is groter naarmate iemand meer, vaker of langer aan HDI is blootgesteld.
Het RIVM onderzoekt sinds 2019 of er wetenschappelijke aanwijzingen zijn voor een verband tussen blootstelling aan HDI en schadelijke gezondheidseffecten. In het eerste onderzoek (gepubliceerd in 2020) toonde het RIVM aan dat beroepsmatige blootstelling schadelijk is voor de gezondheid van werknemers en bepaalde ziekten kan veroorzaken. Onderzoek uit 2021 op basis van de nieuwste wetenschappelijke kennis, bevestigt deze conclusies. Er zijn geen nieuwe gezondheidseffecten in relatie tot blootstelling aan HDI aangetoond.
Blootstelling aan HDI kan de volgende ziekten veroorzaken: vormen van astma, neus- en oogslijmvliesontsteking, contactdermatitis en de zeldzame longaandoening Hypersensitivity Pneumonitis. Er zijn geen aanwijzingen dat HDI kankerverwekkend is.
Between 1984 and 2006, Ministry of Defence personnel maintained American equipment at the so-called POMS sites (POMS stands for Prepositioned Organizational Materiel Storage) in the Netherlands. They worked with several materials, including Chemical Agent Resistant Coating (CARC), a protective top coating for army vehicles. It is possible that workers were exposed to components of CARC during maintenance activities. Hexamethylene di-isocyanate, or HDI, is an important ingredient of this coating and has hazardous properties. The risk of becoming sick increases with the intensity, frequency and duration of exposure to HDI. Since 2019, RIVM studies whether there is scientific evidence for a relation between exposure to HDI and adverse health effects. In the first study (published in 2020), RIVM showed that occupational exposure causes adverse health effects and can cause certain diseases. The study carried out in 2021, based on the latest scientific knowledge, confirms these conclusions. No evidence was found indicating new adverse health effects due to HDI exposure. Exposure to HDI has been linked to the following diseases: different forms of asthma, inflammation of the mucous membranes of the nose and eye, contact dermatitis, and the rare lung disorder Hypersensitivity Pneumonitis. There are no indications that HDI is carcinogenic.
Between 1984 and 2006, Ministry of Defence personnel maintained American equipment at the so-called POMS sites (POMS stands for Prepositioned Organizational Materiel Storage) in the Netherlands. They worked with several materials, including Chemical Agent Resistant Coating (CARC), a protective top coating for army vehicles. It is possible that workers were exposed to components of CARC during maintenance activities. Hexamethylene di-isocyanate, or HDI, is an important ingredient of this coating and has hazardous properties. The risk of becoming sick increases with the intensity, frequency and duration of exposure to HDI. Since 2019, RIVM studies whether there is scientific evidence for a relation between exposure to HDI and adverse health effects. In the first study (published in 2020), RIVM showed that occupational exposure causes adverse health effects and can cause certain diseases. The study carried out in 2021, based on the latest scientific knowledge, confirms these conclusions. No evidence was found indicating new adverse health effects due to HDI exposure. Exposure to HDI has been linked to the following diseases: different forms of asthma, inflammation of the mucous membranes of the nose and eye, contact dermatitis, and the rare lung disorder Hypersensitivity Pneumonitis. There are no indications that HDI is carcinogenic.
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
Ministerie van Defensie