Proefbestraling van ratten met verschillende doseringen rontgenstraling t.b.v. de Granuloma Pouch Assay van het Laboratorium voor Carcinogenese en Mutagenese
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Type
Report
Language
nl
Date
1990-01-31
Research Projects
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Title
Proefbestraling van ratten met verschillende
doseringen rontgenstraling t.b.v. de Granuloma Pouch Assay van het
Laboratorium voor Carcinogenese en Mutagenese
Translated Title
Test irradiations of rats with different doses
X-rays for the Granuloma Pouch Assay of the Laboratory for Carcinogenesis
and Mutagenesis
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Abstract
Abstract niet beschikbaar
The Laboratory of Carcinogenesis and Mutagenesis (LCM) operates a programme on Granuloma Pouch Assay. This technique is used to determine various genotoxic effects induced by radiations and for chemicals in a mesenchymal tissue (subcutaneous fibroblasts) of the rat. In the framework of this assay test experiments were performed in which 6 rats were irradiated with X-rays. The group of 6 rats was divided into three subgroups of 2 animals each, coded 1 (dose=2Gy), 2 (dose=6GY) and 3 (dose=10Gy). The purpose of these preliminary tests is to check wether the applied doses will meet further requirements for assessing the biological endpoints, the capacity involved and the experimental setup.
The Laboratory of Carcinogenesis and Mutagenesis (LCM) operates a programme on Granuloma Pouch Assay. This technique is used to determine various genotoxic effects induced by radiations and for chemicals in a mesenchymal tissue (subcutaneous fibroblasts) of the rat. In the framework of this assay test experiments were performed in which 6 rats were irradiated with X-rays. The group of 6 rats was divided into three subgroups of 2 animals each, coded 1 (dose=2Gy), 2 (dose=6GY) and 3 (dose=10Gy). The purpose of these preliminary tests is to check wether the applied doses will meet further requirements for assessing the biological endpoints, the capacity involved and the experimental setup.
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